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- W2190204638 abstract "The therapeutic potential of miRNA (miR) in cancer is limited by the lack of efficient delivery vehicles. Here, we show that a self-assembled dual-colour RNA-triple-helix structure comprising two miRNAs-a miR mimic (tumour suppressor miRNA) and an antagomiR (oncomiR inhibitor)-provides outstanding capability to synergistically abrogate tumours. Conjugation of RNA triple helices to dendrimers allows the formation of stable triplex nanoparticles, which form an RNA-triple-helix adhesive scaffold upon interaction with dextran aldehyde, the latter able to chemically interact and adhere to natural tissue amines in the tumour. We also show that the self-assembled RNA-triple-helix conjugates remain functional in vitro and in vivo, and that they lead to nearly 90% levels of tumour shrinkage two weeks post-gel implantation in a triple-negative breast cancer mouse model. Our findings suggest that the RNA-triple-helix hydrogels can be used as an efficient anticancer platform to locally modulate the expression of endogenous miRs in cancer." @default.
- W2190204638 created "2016-06-24" @default.
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- W2190204638 date "2015-12-07" @default.
- W2190204638 modified "2023-10-06" @default.
- W2190204638 title "Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment" @default.
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- W2190204638 doi "https://doi.org/10.1038/nmat4497" @default.
- W2190204638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6594154" @default.
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