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- W2190209222 abstract "Down syndrome (DS) is the most common cause of genetic intellectual disability, and the trisomy 21 is associated with more than 80 clinical traits, including higher risk for epilepsy. Several hypotheses have been put forward to explain the mechanisms underlying increased seizure susceptibility in DS: inherent structural brain abnormalities, abnormal cortical lamination, disruption of normal dendritic morphology, and underdeveloped synaptic profiles. A deficiency or loss of GABA inhibition is hypothesized to be one of the main alterations related to the epileptogenic process. Paradoxically, enhanced GABA inhibition has also been reported to promote seizures. One major functional abnormality observed in the brains of individuals and mouse models with DS appears to be an imbalance between excitatory and inhibitory neurotransmission, with excessive inhibitory brain function. This review discusses the GABAergic system in the human DS brain and the possible implication of the GABAergic network circuit in the epileptogenic process in individuals where the pathogenetic basis for epilepsy is unknown." @default.
- W2190209222 created "2016-06-24" @default.
- W2190209222 creator A5038258186 @default.
- W2190209222 creator A5044071998 @default.
- W2190209222 creator A5084263713 @default.
- W2190209222 date "2015-12-01" @default.
- W2190209222 modified "2023-10-02" @default.
- W2190209222 title "Cerebal overinhibition could be the basis for the high prevalence of epilepsy in persons with Down syndrome" @default.
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- W2190209222 doi "https://doi.org/10.1016/j.yebeh.2015.10.004" @default.
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