Matches in SemOpenAlex for { <https://semopenalex.org/work/W2190279357> ?p ?o ?g. }
- W2190279357 endingPage "e0144694" @default.
- W2190279357 startingPage "e0144694" @default.
- W2190279357 abstract "Several lines of evidence suggest a regulatory role of histamine in circadian rhythms, but little is known about signaling pathways that would be involved in such a putative role. The aim of this study was to examine whether histamine mediates its effects on the circadian system through Hrh1 or Hrh3 receptors. We assessed both diurnal and free-running locomotor activity rhythms of Hrh1-/- and Hrh3-/- mice. We also determined the expression of Per1, Per2 and Bmal1 genes in the suprachiasmatic nuclei, several areas of the cerebral cortex and striatum under symmetric 24 h light-dark cycle at zeitgeber times 14 and 6 by using radioactive in situ hybridization. We found no differences between Hrh1-/- and wild type mice in the length, amplitude and mesor of diurnal and free-running activity rhythms as well as in expression of Per1, Per2 and Bmal1 genes in any of the examined brain structures. The amplitude of free-running activity rhythm of the Hrh3-/- mice was significantly flattened, whereas the expression of the clock genes in Hrh3-/- mice was similar to the wild type animals in all of the assessed brain structures. Therefore, the knockout of Hrh1 receptor had no effects on the circadian rhythm of spontaneous locomotion, and a knockout of Hrh3 receptor caused a substantial reduction of free-running activity rhythm amplitude, but none of these knockout models affected the expression patterns of the core clock genes in any of the studied brain structures." @default.
- W2190279357 created "2016-06-24" @default.
- W2190279357 creator A5014800650 @default.
- W2190279357 creator A5061176617 @default.
- W2190279357 creator A5076400987 @default.
- W2190279357 date "2015-12-10" @default.
- W2190279357 modified "2023-09-24" @default.
- W2190279357 title "On the Role of Histamine Receptors in the Regulation of Circadian Rhythms" @default.
- W2190279357 cites W119514703 @default.
- W2190279357 cites W1664200544 @default.
- W2190279357 cites W1935519468 @default.
- W2190279357 cites W1964922357 @default.
- W2190279357 cites W1968312067 @default.
- W2190279357 cites W1973240932 @default.
- W2190279357 cites W1986608768 @default.
- W2190279357 cites W1990170597 @default.
- W2190279357 cites W1990809315 @default.
- W2190279357 cites W1992192643 @default.
- W2190279357 cites W1993678663 @default.
- W2190279357 cites W1996158037 @default.
- W2190279357 cites W2004914129 @default.
- W2190279357 cites W2027580915 @default.
- W2190279357 cites W2031977191 @default.
- W2190279357 cites W2032530293 @default.
- W2190279357 cites W2035089766 @default.
- W2190279357 cites W2042040860 @default.
- W2190279357 cites W2044134989 @default.
- W2190279357 cites W2045647450 @default.
- W2190279357 cites W2046223918 @default.
- W2190279357 cites W2047886249 @default.
- W2190279357 cites W2048466060 @default.
- W2190279357 cites W2056642586 @default.
- W2190279357 cites W2057522076 @default.
- W2190279357 cites W2058159881 @default.
- W2190279357 cites W2062320582 @default.
- W2190279357 cites W2066533504 @default.
- W2190279357 cites W2066821552 @default.
- W2190279357 cites W2068582018 @default.
- W2190279357 cites W2068736404 @default.
- W2190279357 cites W2075316492 @default.
- W2190279357 cites W2078689239 @default.
- W2190279357 cites W2082893143 @default.
- W2190279357 cites W2084889124 @default.
- W2190279357 cites W2091181468 @default.
- W2190279357 cites W2095472576 @default.
- W2190279357 cites W2119696362 @default.
- W2190279357 cites W2124737554 @default.
- W2190279357 cites W2130270464 @default.
- W2190279357 cites W2137252071 @default.
- W2190279357 cites W2139751400 @default.
- W2190279357 cites W2150108640 @default.
- W2190279357 cites W2152253642 @default.
- W2190279357 cites W2418508915 @default.
- W2190279357 doi "https://doi.org/10.1371/journal.pone.0144694" @default.
- W2190279357 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4675540" @default.
- W2190279357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26660098" @default.
- W2190279357 hasPublicationYear "2015" @default.
- W2190279357 type Work @default.
- W2190279357 sameAs 2190279357 @default.
- W2190279357 citedByCount "8" @default.
- W2190279357 countsByYear W21902793572016 @default.
- W2190279357 countsByYear W21902793572017 @default.
- W2190279357 countsByYear W21902793572019 @default.
- W2190279357 countsByYear W21902793572020 @default.
- W2190279357 countsByYear W21902793572021 @default.
- W2190279357 countsByYear W21902793572022 @default.
- W2190279357 crossrefType "journal-article" @default.
- W2190279357 hasAuthorship W2190279357A5014800650 @default.
- W2190279357 hasAuthorship W2190279357A5061176617 @default.
- W2190279357 hasAuthorship W2190279357A5076400987 @default.
- W2190279357 hasBestOaLocation W21902793571 @default.
- W2190279357 hasConcept C1122143 @default.
- W2190279357 hasConcept C121446783 @default.
- W2190279357 hasConcept C126322002 @default.
- W2190279357 hasConcept C134018914 @default.
- W2190279357 hasConcept C169760540 @default.
- W2190279357 hasConcept C170493617 @default.
- W2190279357 hasConcept C182704531 @default.
- W2190279357 hasConcept C184738001 @default.
- W2190279357 hasConcept C201176492 @default.
- W2190279357 hasConcept C21786239 @default.
- W2190279357 hasConcept C2779064383 @default.
- W2190279357 hasConcept C2779317972 @default.
- W2190279357 hasConcept C2780360009 @default.
- W2190279357 hasConcept C38606739 @default.
- W2190279357 hasConcept C54355233 @default.
- W2190279357 hasConcept C71924100 @default.
- W2190279357 hasConcept C86803240 @default.
- W2190279357 hasConcept C95444343 @default.
- W2190279357 hasConceptScore W2190279357C1122143 @default.
- W2190279357 hasConceptScore W2190279357C121446783 @default.
- W2190279357 hasConceptScore W2190279357C126322002 @default.
- W2190279357 hasConceptScore W2190279357C134018914 @default.
- W2190279357 hasConceptScore W2190279357C169760540 @default.
- W2190279357 hasConceptScore W2190279357C170493617 @default.
- W2190279357 hasConceptScore W2190279357C182704531 @default.
- W2190279357 hasConceptScore W2190279357C184738001 @default.
- W2190279357 hasConceptScore W2190279357C201176492 @default.