Matches in SemOpenAlex for { <https://semopenalex.org/work/W2190323360> ?p ?o ?g. }
- W2190323360 abstract "In cognitively normal (CN) elderly individuals, white matter hyperintensities (WMH) are commonly viewed as a marker of cerebral small vessel disease (SVD). SVD is due to exposure to systemic vascular injury processes associated with highly prevalent vascular risk factors (VRFs) such as hypertension, high cholesterol, and diabetes. However, cerebral amyloid accumulation is also prevalent in this population and is associated with WMH accrual. Therefore, we examined the independent associations of amyloid burden and VRFs with WMH burden in CN elderly individuals with low to moderate vascular risk. Participants (n = 150) in the Alzheimer's Disease Neuroimaging Initiative (ADNI) received fluid attenuated inversion recovery (FLAIR) MRI at study entry. Total WMH volume was calculated from FLAIR images co-registered with structural MRI. Amyloid burden was determined by cerebrospinal fluid Aβ1-42 levels. Clinical histories of VRFs, as well as current measurements of vascular status, were recorded during a baseline clinical evaluation. We tested ridge regression models for independent associations and interactions of elevated blood pressure (BP) and amyloid to total WMH volume. We found that greater amyloid burden and a clinical history of hypertension were independently associated with greater WMH volume. In addition, elevated BP modified the association between amyloid and WMH, such that those with either current or past evidence of elevated BP had greater WMH volumes at a given burden of amyloid. These findings are consistent with the hypothesis that cerebral amyloid accumulation and VRFs are independently associated with clinically latent white matter damage represented by WMHs. The potential contribution of amyloid to WMHs should be further explored, even among elderly individuals without cognitive impairment and with limited VRF exposure." @default.
- W2190323360 created "2016-06-24" @default.
- W2190323360 creator A5001598199 @default.
- W2190323360 creator A5009052142 @default.
- W2190323360 creator A5043086041 @default.
- W2190323360 creator A5044611916 @default.
- W2190323360 creator A5054637868 @default.
- W2190323360 creator A5071825455 @default.
- W2190323360 creator A5075840424 @default.
- W2190323360 date "2015-12-01" @default.
- W2190323360 modified "2023-10-14" @default.
- W2190323360 title "Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly" @default.
- W2190323360 cites W1496503766 @default.
- W2190323360 cites W1541357272 @default.
- W2190323360 cites W1871783318 @default.
- W2190323360 cites W1969443632 @default.
- W2190323360 cites W1976866382 @default.
- W2190323360 cites W1977714477 @default.
- W2190323360 cites W1978316308 @default.
- W2190323360 cites W1980842500 @default.
- W2190323360 cites W1990427131 @default.
- W2190323360 cites W1993210620 @default.
- W2190323360 cites W1997794971 @default.
- W2190323360 cites W2005980822 @default.
- W2190323360 cites W2008744058 @default.
- W2190323360 cites W2020753774 @default.
- W2190323360 cites W2025457866 @default.
- W2190323360 cites W2026781040 @default.
- W2190323360 cites W2027085877 @default.
- W2190323360 cites W2034419143 @default.
- W2190323360 cites W2034715074 @default.
- W2190323360 cites W2050209856 @default.
- W2190323360 cites W2055568131 @default.
- W2190323360 cites W2057164916 @default.
- W2190323360 cites W2060240841 @default.
- W2190323360 cites W2073161926 @default.
- W2190323360 cites W2092665786 @default.
- W2190323360 cites W2099511111 @default.
- W2190323360 cites W2100428051 @default.
- W2190323360 cites W2106649637 @default.
- W2190323360 cites W2110395308 @default.
- W2190323360 cites W2110772266 @default.
- W2190323360 cites W2126999263 @default.
- W2190323360 cites W2128581044 @default.
- W2190323360 cites W2131036135 @default.
- W2190323360 cites W2132752715 @default.
- W2190323360 cites W2136210722 @default.
- W2190323360 cites W2144971762 @default.
- W2190323360 cites W2148092884 @default.
- W2190323360 cites W2158742097 @default.
- W2190323360 cites W2159625467 @default.
- W2190323360 cites W2165815203 @default.
- W2190323360 cites W2166416515 @default.
- W2190323360 cites W2168103648 @default.
- W2190323360 cites W2745668955 @default.
- W2190323360 cites W4206495155 @default.
- W2190323360 cites W4244273072 @default.
- W2190323360 doi "https://doi.org/10.3389/fnagi.2015.00221" @default.
- W2190323360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4664630" @default.
- W2190323360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26648866" @default.
- W2190323360 hasPublicationYear "2015" @default.
- W2190323360 type Work @default.
- W2190323360 sameAs 2190323360 @default.
- W2190323360 citedByCount "45" @default.
- W2190323360 countsByYear W21903233602016 @default.
- W2190323360 countsByYear W21903233602017 @default.
- W2190323360 countsByYear W21903233602018 @default.
- W2190323360 countsByYear W21903233602019 @default.
- W2190323360 countsByYear W21903233602020 @default.
- W2190323360 countsByYear W21903233602021 @default.
- W2190323360 countsByYear W21903233602022 @default.
- W2190323360 countsByYear W21903233602023 @default.
- W2190323360 crossrefType "journal-article" @default.
- W2190323360 hasAuthorship W2190323360A5001598199 @default.
- W2190323360 hasAuthorship W2190323360A5009052142 @default.
- W2190323360 hasAuthorship W2190323360A5043086041 @default.
- W2190323360 hasAuthorship W2190323360A5044611916 @default.
- W2190323360 hasAuthorship W2190323360A5054637868 @default.
- W2190323360 hasAuthorship W2190323360A5071825455 @default.
- W2190323360 hasAuthorship W2190323360A5075840424 @default.
- W2190323360 hasBestOaLocation W21903233601 @default.
- W2190323360 hasConcept C101070640 @default.
- W2190323360 hasConcept C118552586 @default.
- W2190323360 hasConcept C126322002 @default.
- W2190323360 hasConcept C126838900 @default.
- W2190323360 hasConcept C142724271 @default.
- W2190323360 hasConcept C143409427 @default.
- W2190323360 hasConcept C146638467 @default.
- W2190323360 hasConcept C164705383 @default.
- W2190323360 hasConcept C2777633098 @default.
- W2190323360 hasConcept C2779134260 @default.
- W2190323360 hasConcept C2781073650 @default.
- W2190323360 hasConcept C2781192897 @default.
- W2190323360 hasConcept C502032728 @default.
- W2190323360 hasConcept C58693492 @default.
- W2190323360 hasConcept C71924100 @default.
- W2190323360 hasConceptScore W2190323360C101070640 @default.
- W2190323360 hasConceptScore W2190323360C118552586 @default.
- W2190323360 hasConceptScore W2190323360C126322002 @default.
- W2190323360 hasConceptScore W2190323360C126838900 @default.