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- W2190680488 abstract "Innate immunity offers the first line of defense against infections and other types of danger such as tumorigenesis. Its discovery provides tremendous therapeutic opportunities for numerous human diseases. Delving into the structural basis of signal transduction by innate immune receptors, our lab has recently helped to establish the new paradigm in which innate immune receptors transduce ligand-binding signals through formation of higher-order assemblies containing intracellular adapters, signaling enzymes and their substrates. These large signalosome assemblies may be visible under light microscopy as punctate structures in the µm scale, connecting to the underlying molecular structures in the nm scale. They drive proximity-induced enzyme activation, and provide a mechanism for signaling amplification by nucleated polymerization. These supramolecular signaling complexes also open new questions on their cellular organization and mode of regulation, pose challenges to our methodology, and afford valuable implications in drug discovery against these medically important pathways." @default.
- W2190680488 created "2016-06-24" @default.
- W2190680488 creator A5015056220 @default.
- W2190680488 creator A5016855239 @default.
- W2190680488 date "2015-10-28" @default.
- W2190680488 modified "2023-09-27" @default.
- W2190680488 title "Supramolecular organizing centers (SMOCs) as signaling machines in innate immune activation" @default.
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- W2190680488 doi "https://doi.org/10.1007/s11427-015-4951-z" @default.
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