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• W2190691769 abstract "Publisher Summary Being obligate intracellular parasites, viruses are dependent on the metabolic pathways of the host cell for their replication. Therefore, virus and host cells are intimately connected, and an effective antiviral agent must be able to distinguish virus-related enzymes from the host cell material itself. The search for antitumour agents generated a great deal of interest in DNA synthesis inhibitors. While reviewing the possibilities for antiviral chemotherapy, the best guideline is the viral replicative cycle. This replication step differs in RNA and DNA viruses, but mRNA is produced in all. Although all viruses follow this replicative cycle, different virus families may differ considerably from one another at one or more steps of the cycle. Useful inhibitors are generally specific for one family of virus and, in some cases, to individual members of that family. In the past decade, there has been a rapid progress in both understanding of antiviral therapy and the number of antiviral agents on the market. Increasingly, combinations of agents are being used to achieve synergistic inhibition of viruses, to delay resistance, and to decrease dosages of toxic drugs. Future directions include the use of molecular biologic techniques to identify enzymes unique in viral replication and computer-aided drug design to interfere with these enzymes or receptors." @default.
• W2190691769 created "2016-06-24" @default.
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• W2190691769 date "2002-01-01" @default.
• W2190691769 modified "2023-09-27" @default.
• W2190691769 title "Classes of Antiviral Drugs" @default.
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• W2190691769 doi "https://doi.org/10.1016/b978-044450884-3/50001-5" @default.
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