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- W2190976684 abstract "Chronic hepatitis B infection affects over 240 million people worldwide, with long-term morbidity such as cirrhosis and hepatocellular carcinoma (HCC) accounting for around 600,000 deaths annually [ [1] World Health Organization. Hepatitis B Fact sheet No. 204, 2012. Cited 24 Oct 2012. Available from URL: http://www.who.int/mediacentre/factsheets/fs204/en/. Google Scholar ]. Since the discovery of hepatitis B virus (HBV) by Blumberg in 1965, progress has been impressive with the availability in the 1980 of HBV vaccine and in the 2000 the development of potent antiviral agents resulting in an improved long-term outcome. Despite the fact that the WHO recommends universal vaccination against hepatitis B to ultimately eliminate HBV (this recommendation has been progressively implemented to reach 168 countries), the global burden of HBV-related disease is still substantial. A nationwide hepatitis B vaccination program was implemented in Taiwan in 1984, leading to a rapid decrease in the incidence of hepatocellular carcinoma in children [ [2] Chang M.H. Chen C.J. Lai M.S. Hsu H.M. Wu T.C. Kong M.S. et al. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group. N Engl J Med. 1997; 336: 1855-1859 Crossref PubMed Scopus (1587) Google Scholar ]. Changing incidence patterns of hepatocellular carcinoma among age groups in TaiwanJournal of HepatologyVol. 63Issue 6PreviewPrimary liver cancer is the second leading cause of cancer-related deaths worldwide [1], including Taiwan [2,3]. The incidence rate of primary liver cancer in Taiwan is more than 10-fold that of other areas of the world such as Australia, New Zealand, and those in South America and Northern Europe [1,4]. The numbers of newly diagnosed cases and deaths reported in 2011 were approximately 11,000 and 8000, respectively [5]. The overall mortality rate accounts for nearly 70% of the incidence rate. This reflects a poor prognosis of primary liver cancer, which can become a major threat to the health of Taiwanese people. Full-Text PDF" @default.
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- W2190976684 date "2015-12-01" @default.
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- W2190976684 title "Universal hepatitis B vaccination: The only way to eliminate hepatocellular carcinoma?" @default.
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- W2190976684 doi "https://doi.org/10.1016/j.jhep.2015.10.001" @default.
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