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- W2190990710 abstract "Nitrone-containing compounds are commonly employed as spin traps of free radical species in chemical and biological studies. Some molecules as α-phenyl-N-t-butyl nitrone (PBN) and its derivatives have been tested as potential drugs to treat oxidative stress related diseases, as Alzheimer and stroke for example. In this work we report the design and the synthesis of α-aryl-N-aryl nitrones and their cytoprotection profile on human neuroblastoma cells (SH-SY5Y) under induced oxidative stress. All the nine synthesized nitrones showed a significant response at low micromolar concentration. The selected compound 8 (α-phenyl-N-phenyl nitrone) increased the reduced glutathione (GSH) levels by 65% and lowered the necrotic cell death from 25.8% to 3.8%. Based on our data, the designed highly conjugated nitrone double-bond skeleton can be considered as a good scaffold for further studies regarding oxidative stress-related diseases." @default.
- W2190990710 created "2016-06-24" @default.
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- W2190990710 date "2016-01-01" @default.
- W2190990710 modified "2023-09-27" @default.
- W2190990710 title "α-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus" @default.
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- W2190990710 doi "https://doi.org/10.1016/j.bmc.2015.12.007" @default.
- W2190990710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26707843" @default.
- W2190990710 hasPublicationYear "2016" @default.
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