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- W2191006082 endingPage "844" @default.
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- W2191006082 abstract "In mammals, each olfactory sensory neuron randomly expresses one, and only one, olfactory receptor (OR)—a phenomenon called the “one-neuron-one-receptor” rule. Although extensively studied, this rule was never proven for all ~1,000 OR genes in one cell at once, and little is known about its dynamics. Here, we directly tested this rule by single-cell transcriptomic sequencing of 178 cells from the main olfactory epithelium of adult and newborn mice. To our surprise, a subset of cells expressed multiple ORs. Most of these cells were developmentally immature. Our results illustrated how the “one-neuron-one-receptor” rule may have been established: At first, a single neuron temporarily expressed multiple ORs—seemingly violating the rule—and then all but one OR were eliminated. This work provided experimental evidence that epigenetic regulation in the olfactory system selects a single OR by suppressing a few transiently expressed ORs in a single cell during development." @default.
- W2191006082 created "2016-06-24" @default.
- W2191006082 creator A5027395038 @default.
- W2191006082 creator A5033900061 @default.
- W2191006082 creator A5085943317 @default.
- W2191006082 date "2015-12-01" @default.
- W2191006082 modified "2023-10-15" @default.
- W2191006082 title "Olfactory sensory neurons transiently express multiple olfactory receptors during development" @default.
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- W2191006082 doi "https://doi.org/10.15252/msb.20156639" @default.
- W2191006082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4704490" @default.
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