Matches in SemOpenAlex for { <https://semopenalex.org/work/W2191007551> ?p ?o ?g. }
- W2191007551 endingPage "704" @default.
- W2191007551 startingPage "696" @default.
- W2191007551 abstract "Galanin, a 29-amino-acid neuropeptide, is generally viewed as an inhibitory neuromodulator in a variety of central systems. Galanin expression is upregulated in the cholinergic basal forebrain nuclei in Alzheimer's disease (AD) and is postulated to play an important role in memory and cognitive function. In this study, application of galanin to acutely dissociated rat neurons from the basal forebrain nucleus diagonal band of Broca (DBB), caused a decrease in whole cell voltage-activated currents in a majority of cells. Galanin reduces a suite of potassium currents, including calcium-activated potassium (I(C)), the delayed rectifier (I(K)), and transient outward potassium (I(A)) conductances, but not calcium or sodium currents. Under current-clamp conditions, application of galanin evoked an increase in excitability and a loss of accommodation in cholinergic DBB neurons. Using single-cell RT-PCR technique, we determined that galanin actions were specific to cholinergic, but not GABAergic DBB neurons The notion that galanin plays a deleterious role in AD is based, in part, on galanin hyperinnervation of cholinergic cells in the basal forebrain of AD patients, its ability to depress acetylcholine release and its inhibitory actions at other CNS sites. However, our results suggest that by virtue of its excitatory actions on cholinergic neurons, galanin may in fact play a compensatory role by augmenting the release of acetylcholine from remaining cholinergic basal forebrain neurons. This action might serve to delay the progression of AD pathology linked to a reduction in central cholinergic tone." @default.
- W2191007551 created "2016-06-24" @default.
- W2191007551 creator A5047777210 @default.
- W2191007551 creator A5067461149 @default.
- W2191007551 creator A5078685685 @default.
- W2191007551 creator A5091820610 @default.
- W2191007551 date "2002-02-01" @default.
- W2191007551 modified "2023-10-18" @default.
- W2191007551 title "Novel Excitatory Actions of Galanin on Rat Cholinergic Basal Forebrain Neurons: Implications for Its Role in Alzheimer's Disease" @default.
- W2191007551 cites W1562990864 @default.
- W2191007551 cites W1570612396 @default.
- W2191007551 cites W1712783605 @default.
- W2191007551 cites W1960189231 @default.
- W2191007551 cites W1968136188 @default.
- W2191007551 cites W1968908922 @default.
- W2191007551 cites W1972046379 @default.
- W2191007551 cites W1980765711 @default.
- W2191007551 cites W1982129451 @default.
- W2191007551 cites W1987737360 @default.
- W2191007551 cites W1991192535 @default.
- W2191007551 cites W1993938009 @default.
- W2191007551 cites W1994906667 @default.
- W2191007551 cites W1995348446 @default.
- W2191007551 cites W2008723603 @default.
- W2191007551 cites W2011399935 @default.
- W2191007551 cites W2014197067 @default.
- W2191007551 cites W2017136928 @default.
- W2191007551 cites W2021583640 @default.
- W2191007551 cites W2023987155 @default.
- W2191007551 cites W2024550999 @default.
- W2191007551 cites W2025760411 @default.
- W2191007551 cites W2031290586 @default.
- W2191007551 cites W2037260170 @default.
- W2191007551 cites W2039771500 @default.
- W2191007551 cites W2045776001 @default.
- W2191007551 cites W2047507533 @default.
- W2191007551 cites W2047718988 @default.
- W2191007551 cites W2053083490 @default.
- W2191007551 cites W2056135189 @default.
- W2191007551 cites W2058659511 @default.
- W2191007551 cites W2063482618 @default.
- W2191007551 cites W2067267153 @default.
- W2191007551 cites W2071224161 @default.
- W2191007551 cites W2074628862 @default.
- W2191007551 cites W2074838365 @default.
- W2191007551 cites W2077693485 @default.
- W2191007551 cites W2080600565 @default.
- W2191007551 cites W2081318242 @default.
- W2191007551 cites W2088364159 @default.
- W2191007551 cites W2090952180 @default.
- W2191007551 cites W2106979137 @default.
- W2191007551 cites W2127208746 @default.
- W2191007551 cites W2137449277 @default.
- W2191007551 cites W2139341827 @default.
- W2191007551 cites W2142941945 @default.
- W2191007551 cites W2156657510 @default.
- W2191007551 cites W2164060165 @default.
- W2191007551 cites W2170633533 @default.
- W2191007551 cites W2399780838 @default.
- W2191007551 cites W2415335114 @default.
- W2191007551 cites W2467293683 @default.
- W2191007551 doi "https://doi.org/10.1152/jn.00416.2001" @default.
- W2191007551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11826038" @default.
- W2191007551 hasPublicationYear "2002" @default.
- W2191007551 type Work @default.
- W2191007551 sameAs 2191007551 @default.
- W2191007551 citedByCount "57" @default.
- W2191007551 countsByYear W21910075512012 @default.
- W2191007551 countsByYear W21910075512013 @default.
- W2191007551 countsByYear W21910075512014 @default.
- W2191007551 countsByYear W21910075512015 @default.
- W2191007551 countsByYear W21910075512016 @default.
- W2191007551 countsByYear W21910075512019 @default.
- W2191007551 crossrefType "journal-article" @default.
- W2191007551 hasAuthorship W2191007551A5047777210 @default.
- W2191007551 hasAuthorship W2191007551A5067461149 @default.
- W2191007551 hasAuthorship W2191007551A5078685685 @default.
- W2191007551 hasAuthorship W2191007551A5091820610 @default.
- W2191007551 hasConcept C104966671 @default.
- W2191007551 hasConcept C118303440 @default.
- W2191007551 hasConcept C126322002 @default.
- W2191007551 hasConcept C134018914 @default.
- W2191007551 hasConcept C169760540 @default.
- W2191007551 hasConcept C170493617 @default.
- W2191007551 hasConcept C17077164 @default.
- W2191007551 hasConcept C185592680 @default.
- W2191007551 hasConcept C19519825 @default.
- W2191007551 hasConcept C22885893 @default.
- W2191007551 hasConcept C2775910092 @default.
- W2191007551 hasConcept C2776287375 @default.
- W2191007551 hasConcept C2779715522 @default.
- W2191007551 hasConcept C529278444 @default.
- W2191007551 hasConcept C71924100 @default.
- W2191007551 hasConcept C86803240 @default.
- W2191007551 hasConceptScore W2191007551C104966671 @default.
- W2191007551 hasConceptScore W2191007551C118303440 @default.
- W2191007551 hasConceptScore W2191007551C126322002 @default.
- W2191007551 hasConceptScore W2191007551C134018914 @default.