FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2191098501> ?p ?o ?g. }

• W2191098501 endingPage "102" @default.
• W2191098501 startingPage "94" @default.
• W2191098501 abstract "Olanzapine, an atypical antipsychotic, is efficient in stress associated psychiatric diseases, but its effect on the liver, a primary organ for drug activation and detoxification, still remains unclear. The effect of olanzapine administration (7.5 mg/kg/day), on rat hepatic glutathione (GSH)-dependent defense and proinflammatory cytokines following 6 weeks of chronic social isolation (CSIS), which causes depressive- and anxiety-like behavior in adult male Wistar rats, was investigated. The subcellular distribution of nuclear factor-κB (NF-κB), cytosolic inducible nitric oxide synthase (iNOS) protein levels and hepatic histological alterations were also determined. Decreased GSH content and glutathione reductase activity associated with increased catalase and glutathione S-transferase activity following CSIS indicated hepatic oxidative stress. Moreover, CSIS caused NF-κB nuclear translocation and the concomitant increase in iNOS together with increase in interleukin-1beta and tumor necrosis factor alpha protein levels, but no effect on interleukin-6. Olanzapine treatment suppressed NF-κB activation and iNOS expression and caused modulation of GSH-dependent defense systems but failed to reverse CSIS-induced increase in hepatic proinflammatory cytokines. Portal inflammation, focal hepatocyte necrosis and an increased number of Kupffer cells in CSIS rats (vehicle- or olanzapine-treated) were found. Olanzapine-treated socially reared rats showed portal inflammation and focal hepatocyte necrosis. Data suggest that CSIS compromised GSH-dependent defense, triggered a proinflammatory response and histological alterations in rat liver. Olanzapine treatment partially reversed the alterations in hepatic GSH-dependent defense, but showed no anti-inflammatory effect suggesting that it may provide protective effect against hepatic CSIS-induced oxidative stress, but not against inflammation." @default.
• W2191098501 created "2016-06-24" @default.
• W2191098501 creator A5002897797 @default.
• W2191098501 creator A5020765906 @default.
• W2191098501 creator A5021940782 @default.
• W2191098501 creator A5037182482 @default.
• W2191098501 date "2016-01-01" @default.
• W2191098501 modified "2023-09-26" @default.
• W2191098501 title "Olanzapine modulation of hepatic oxidative stress and inflammation in socially isolated rats" @default.
• W2191098501 cites W1522652277 @default.
• W2191098501 cites W1581414347 @default.
• W2191098501 cites W1775749144 @default.
• W2191098501 cites W1892885382 @default.
• W2191098501 cites W1965438032 @default.
• W2191098501 cites W1967977853 @default.
• W2191098501 cites W1974322420 @default.
• W2191098501 cites W1982402731 @default.
• W2191098501 cites W1984736110 @default.
• W2191098501 cites W1988149166 @default.
• W2191098501 cites W1992616500 @default.
• W2191098501 cites W1995608479 @default.
• W2191098501 cites W1995631390 @default.
• W2191098501 cites W1997225333 @default.
• W2191098501 cites W2006370393 @default.
• W2191098501 cites W2007284121 @default.
• W2191098501 cites W2008246214 @default.
• W2191098501 cites W2018262113 @default.
• W2191098501 cites W2018742347 @default.
• W2191098501 cites W2023089678 @default.
• W2191098501 cites W2025914071 @default.
• W2191098501 cites W2026261400 @default.
• W2191098501 cites W2028201169 @default.
• W2191098501 cites W2029226467 @default.
• W2191098501 cites W2029631602 @default.
• W2191098501 cites W2032397906 @default.
• W2191098501 cites W2035601252 @default.
• W2191098501 cites W2036008786 @default.
• W2191098501 cites W2038749103 @default.
• W2191098501 cites W2044096147 @default.
• W2191098501 cites W2044381985 @default.
• W2191098501 cites W2045775376 @default.
• W2191098501 cites W2047363102 @default.
• W2191098501 cites W2051061580 @default.
• W2191098501 cites W2053272623 @default.
• W2191098501 cites W2055292959 @default.
• W2191098501 cites W2062682953 @default.
• W2191098501 cites W2064965507 @default.
• W2191098501 cites W2069113690 @default.
• W2191098501 cites W2072997843 @default.
• W2191098501 cites W2074874853 @default.
• W2191098501 cites W2075200744 @default.
• W2191098501 cites W2077821705 @default.
• W2191098501 cites W2083252023 @default.
• W2191098501 cites W2092034902 @default.
• W2191098501 cites W2093978152 @default.
• W2191098501 cites W2094701534 @default.
• W2191098501 cites W2100837269 @default.
• W2191098501 cites W2111757377 @default.
• W2191098501 cites W2117552900 @default.
• W2191098501 cites W2119050929 @default.
• W2191098501 cites W2119704634 @default.
• W2191098501 cites W2129935236 @default.
• W2191098501 cites W2130769213 @default.
• W2191098501 cites W2130837075 @default.
• W2191098501 cites W2132649715 @default.
• W2191098501 cites W2154322840 @default.
• W2191098501 cites W2155271754 @default.
• W2191098501 cites W2156602568 @default.
• W2191098501 cites W2162710197 @default.
• W2191098501 cites W2163426704 @default.
• W2191098501 cites W2166337262 @default.
• W2191098501 cites W2166571566 @default.
• W2191098501 cites W2169714384 @default.
• W2191098501 cites W2331176038 @default.
• W2191098501 doi "https://doi.org/10.1016/j.ejps.2015.10.010" @default.
• W2191098501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26474692" @default.
• W2191098501 hasPublicationYear "2016" @default.
• W2191098501 type Work @default.
• W2191098501 sameAs 2191098501 @default.
• W2191098501 citedByCount "24" @default.
• W2191098501 countsByYear W21910985012016 @default.
• W2191098501 countsByYear W21910985012017 @default.
• W2191098501 countsByYear W21910985012018 @default.
• W2191098501 countsByYear W21910985012019 @default.
• W2191098501 countsByYear W21910985012020 @default.
• W2191098501 countsByYear W21910985012021 @default.
• W2191098501 countsByYear W21910985012022 @default.
• W2191098501 crossrefType "journal-article" @default.
• W2191098501 hasAuthorship W2191098501A5002897797 @default.
• W2191098501 hasAuthorship W2191098501A5020765906 @default.
• W2191098501 hasAuthorship W2191098501A5021940782 @default.
• W2191098501 hasAuthorship W2191098501A5037182482 @default.
• W2191098501 hasConcept C118552586 @default.
• W2191098501 hasConcept C126322002 @default.
• W2191098501 hasConcept C134018914 @default.
• W2191098501 hasConcept C164027704 @default.
• W2191098501 hasConcept C181199279 @default.
• W2191098501 hasConcept C185592680 @default.

• next