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• W2191492783 abstract "In the present review, we summarize advances in our knowledge on the role of the histone H1 family of proteins in breast cancer cells, focusing on their response to progestins. Histone H1 plays a dual role in gene regulation by hormones, both as a structural component of chromatin and as a dynamic modulator of transcription. It contributes to hormonal regulation of the MMTV promoter by stabilizing a homogeneous nucleosome positioning, which reduces basal transcription whereas at the same time promoting progesterone receptor binding and nucleosome remodeling. These combined effects enhance hormone dependent gene transcription, which eventually requires H1 phosphorylation and displacement. Various isoforms of histone H1 have specific functions in differentiated breast cancer cells and compact nucleosomal arrays to different extents in vitro. Genome-wide studies show that histone H1 has a key role in chromatin dynamics of hormone regulated genes. A complex sequence of enzymatic events, including phosphorylation by CDK2, PARylation by PARP1 and the ATP-dependent activity of NURF, are required for H1 displacement and gene de-repression, as a prerequisite for further nucleosome remodeling. Similarly, during hormone-dependent gene repression a dedicated enzymatic mechanism controls H1 deposition at promoters by a complex containing HP1γ, LSD1 and BRG1, the ATPase of the BAF complex. Thus, a broader vision of the histone code should include histone H1, as the linker histone variants actively participate in the regulation of the chromatin structure. How modifications of the core histones tails affect H1 modifications and vice versa is one of the many questions that remains to be addressed to provide a more comprehensive view of the histone cross-talk mechanisms." @default.
• W2191492783 created "2016-06-24" @default.
• W2191492783 creator A5020035920 @default.
• W2191492783 creator A5029586324 @default.
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• W2191492783 date "2016-03-01" @default.
• W2191492783 modified "2023-10-08" @default.
• W2191492783 title "Linker histones in hormonal gene regulation" @default.
• W2191492783 cites W1504034854 @default.
• W2191492783 cites W1646254594 @default.
• W2191492783 cites W1660678623 @default.
• W2191492783 cites W1942467333 @default.
• W2191492783 cites W1964054574 @default.
• W2191492783 cites W1965555526 @default.
• W2191492783 cites W1968492615 @default.
• W2191492783 cites W1969575777 @default.
• W2191492783 cites W1972293204 @default.
• W2191492783 cites W1974761743 @default.
• W2191492783 cites W1983329574 @default.
• W2191492783 cites W1984184017 @default.
• W2191492783 cites W1988626741 @default.
• W2191492783 cites W1989437252 @default.
• W2191492783 cites W1991180478 @default.
• W2191492783 cites W1993822465 @default.
• W2191492783 cites W1994110056 @default.
• W2191492783 cites W2003232929 @default.
• W2191492783 cites W2004202908 @default.
• W2191492783 cites W2005144583 @default.
• W2191492783 cites W2005749687 @default.
• W2191492783 cites W2010189295 @default.
• W2191492783 cites W2010656369 @default.
• W2191492783 cites W2020790775 @default.
• W2191492783 cites W2024666242 @default.
• W2191492783 cites W2025092022 @default.
• W2191492783 cites W2027294913 @default.
• W2191492783 cites W2028445104 @default.
• W2191492783 cites W2037316481 @default.
• W2191492783 cites W2038131926 @default.
• W2191492783 cites W2038483170 @default.
• W2191492783 cites W2038828962 @default.
• W2191492783 cites W2041787701 @default.
• W2191492783 cites W2044219530 @default.
• W2191492783 cites W2046615335 @default.
• W2191492783 cites W2047910474 @default.
• W2191492783 cites W2054984451 @default.
• W2191492783 cites W2057321383 @default.
• W2191492783 cites W2058448711 @default.
• W2191492783 cites W2060321052 @default.
• W2191492783 cites W2066689854 @default.
• W2191492783 cites W2067744908 @default.
• W2191492783 cites W2069824481 @default.
• W2191492783 cites W2071784672 @default.
• W2191492783 cites W2073942818 @default.
• W2191492783 cites W2080479776 @default.
• W2191492783 cites W2083959000 @default.
• W2191492783 cites W2085349339 @default.
• W2191492783 cites W2092638438 @default.
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• W2191492783 cites W2138127544 @default.
• W2191492783 cites W2138576901 @default.
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• W2191492783 cites W2147403429 @default.
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• W2191492783 cites W2154665053 @default.
• W2191492783 cites W2154829160 @default.
• W2191492783 cites W2157031657 @default.
• W2191492783 cites W2158673140 @default.
• W2191492783 cites W2161499647 @default.
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• W2191492783 doi "https://doi.org/10.1016/j.bbagrm.2015.10.016" @default.
• W2191492783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26518266" @default.
• W2191492783 hasPublicationYear "2016" @default.
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