FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2191631278> ?p ?o ?g. }

• W2191631278 endingPage "289" @default.
• W2191631278 startingPage "278" @default.
• W2191631278 abstract "Translation termination in eukaryotes is mediated by release factors: eRF1, which is responsible for stop codon recognition and peptidyl-tRNA hydrolysis, and GTPase eRF3, which stimulates peptide release. Here, we have utilized ribose-specific probes to investigate accessibility of rRNA backbone in complexes formed by association of mRNA- and tRNA-bound human ribosomes with eRF1•eRF3•GMPPNP, eRF1•eRF3•GTP, or eRF1 alone as compared with complexes where the A site is vacant or occupied by tRNA. Our data show which rRNA ribose moieties are protected from attack by the probes in the complexes with release factors and reveal the rRNA regions increasing their accessibility to the probes after the factors bind. These regions in 28S rRNA are helices 43 and 44 in the GTPase associated center, the apical loop of helix 71, and helices 89, 92, and 94 as well as 18S rRNA helices 18 and 34. Additionally, the obtained data suggest that eRF3 neither interacts with the rRNA ribose-phosphate backbone nor dissociates from the complex after GTP hydrolysis. Taken together, our findings provide new information on architecture of the eRF1 binding site on mammalian ribosome at various translation termination steps and on conformational rearrangements induced by binding of the release factors." @default.
• W2191631278 created "2016-06-24" @default.
• W2191631278 creator A5011517204 @default.
• W2191631278 creator A5021828914 @default.
• W2191631278 creator A5033319300 @default.
• W2191631278 creator A5081481979 @default.
• W2191631278 creator A5083542207 @default.
• W2191631278 creator A5088181841 @default.
• W2191631278 date "2015-12-11" @default.
• W2191631278 modified "2023-09-24" @default.
• W2191631278 title "Chemical footprinting reveals conformational changes of 18S and 28S rRNAs at different steps of translation termination on the human ribosome" @default.
• W2191631278 cites W1521738036 @default.
• W2191631278 cites W1925924848 @default.
• W2191631278 cites W1964441674 @default.
• W2191631278 cites W1965764575 @default.
• W2191631278 cites W1965803462 @default.
• W2191631278 cites W1970037668 @default.
• W2191631278 cites W1970590543 @default.
• W2191631278 cites W1971207744 @default.
• W2191631278 cites W1973375500 @default.
• W2191631278 cites W1983435302 @default.
• W2191631278 cites W1987390098 @default.
• W2191631278 cites W1993969571 @default.
• W2191631278 cites W2001999088 @default.
• W2191631278 cites W2003700019 @default.
• W2191631278 cites W2006605454 @default.
• W2191631278 cites W2008359458 @default.
• W2191631278 cites W2017491174 @default.
• W2191631278 cites W2020502541 @default.
• W2191631278 cites W2021487066 @default.
• W2191631278 cites W2034199961 @default.
• W2191631278 cites W2038276231 @default.
• W2191631278 cites W2038940439 @default.
• W2191631278 cites W2039584947 @default.
• W2191631278 cites W2043566555 @default.
• W2191631278 cites W2056372900 @default.
• W2191631278 cites W2056975726 @default.
• W2191631278 cites W2058092857 @default.
• W2191631278 cites W2064089190 @default.
• W2191631278 cites W2070113453 @default.
• W2191631278 cites W2085063254 @default.
• W2191631278 cites W2091328421 @default.
• W2191631278 cites W2093856160 @default.
• W2191631278 cites W2098985194 @default.
• W2191631278 cites W2102442864 @default.
• W2191631278 cites W2104252111 @default.
• W2191631278 cites W2105091046 @default.
• W2191631278 cites W2105326796 @default.
• W2191631278 cites W2113509467 @default.
• W2191631278 cites W2117808511 @default.
• W2191631278 cites W2118501435 @default.
• W2191631278 cites W2119374287 @default.
• W2191631278 cites W2121030623 @default.
• W2191631278 cites W2122695112 @default.
• W2191631278 cites W2131623467 @default.
• W2191631278 cites W2132746070 @default.
• W2191631278 cites W2136211980 @default.
• W2191631278 cites W2139694420 @default.
• W2191631278 cites W2142056356 @default.
• W2191631278 cites W2145473270 @default.
• W2191631278 cites W2148529980 @default.
• W2191631278 cites W2149482038 @default.
• W2191631278 cites W2151284262 @default.
• W2191631278 cites W2158314430 @default.
• W2191631278 cites W2163803825 @default.
• W2191631278 cites W2164754533 @default.
• W2191631278 cites W2171819173 @default.
• W2191631278 cites W2186864552 @default.
• W2191631278 cites W86541428 @default.
• W2191631278 doi "https://doi.org/10.1261/rna.053801.115" @default.
• W2191631278 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4712677" @default.
• W2191631278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26655225" @default.
• W2191631278 hasPublicationYear "2015" @default.
• W2191631278 type Work @default.
• W2191631278 sameAs 2191631278 @default.
• W2191631278 citedByCount "7" @default.
• W2191631278 countsByYear W21916312782016 @default.
• W2191631278 countsByYear W21916312782017 @default.
• W2191631278 countsByYear W21916312782018 @default.
• W2191631278 countsByYear W21916312782019 @default.
• W2191631278 countsByYear W21916312782020 @default.
• W2191631278 countsByYear W21916312782021 @default.
• W2191631278 crossrefType "journal-article" @default.
• W2191631278 hasAuthorship W2191631278A5011517204 @default.
• W2191631278 hasAuthorship W2191631278A5021828914 @default.
• W2191631278 hasAuthorship W2191631278A5033319300 @default.
• W2191631278 hasAuthorship W2191631278A5081481979 @default.
• W2191631278 hasAuthorship W2191631278A5083542207 @default.
• W2191631278 hasAuthorship W2191631278A5088181841 @default.
• W2191631278 hasBestOaLocation W21916312781 @default.
• W2191631278 hasConcept C104317684 @default.
• W2191631278 hasConcept C105580179 @default.
• W2191631278 hasConcept C106774688 @default.
• W2191631278 hasConcept C107824862 @default.
• W2191631278 hasConcept C129194359 @default.
• W2191631278 hasConcept C149364088 @default.
• W2191631278 hasConcept C153957851 @default.
• W2191631278 hasConcept C181199279 @default.

• next