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- W2191709890 abstract "The extent of variation in DNA methylation patterns in healthy individuals is not yet well documented. Identification of inter-individual epigenetic variation is important for understanding phenotypic variation and disease susceptibility. Using neutrophils from a cohort of healthy individuals, we generated base-resolution DNA methylation maps to document inter-individual epigenetic variation. We identified 12851 autosomal inter-individual variably methylated fragments (iVMFs). Gene promoters were the least variable, whereas gene body and upstream regions showed higher variation in DNA methylation. The iVMFs were relatively enriched in repetitive elements compared to non-iVMFs, and were associated with genome regulation and chromatin function elements. Further, variably methylated genes were disproportionately associated with regulation of transcription, responsive function and signal transduction pathways. Transcriptome analysis indicates that iVMF methylation at differentially expressed exons has a positive correlation and local effect on the inclusion of that exon in the mRNA transcript." @default.
- W2191709890 created "2016-06-24" @default.
- W2191709890 creator A5026967054 @default.
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- W2191709890 date "2015-11-27" @default.
- W2191709890 modified "2023-10-12" @default.
- W2191709890 title "Genome-wide DNA methylation map of human neutrophils reveals widespread inter-individual epigenetic variation" @default.
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- W2191709890 doi "https://doi.org/10.1038/srep17328" @default.
- W2191709890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4661471" @default.
- W2191709890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26612583" @default.
- W2191709890 hasPublicationYear "2015" @default.
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