Matches in SemOpenAlex for { <https://semopenalex.org/work/W2191719293> ?p ?o ?g. }
- W2191719293 endingPage "38" @default.
- W2191719293 startingPage "27" @default.
- W2191719293 abstract "Gene activation in metazoans is accompanied by the presence of histone variants H2AZ and H3.3 within promoters and enhancers. It is not known, however, what protein deposits H3.3 into chromatin or whether variant chromatin plays a direct role in gene activation. Here we show that chromatin containing acetylated H2AZ and H3.3 stimulates transcription in vitro. Analysis of the Pol II pre-initiation complex on immobilized chromatin templates revealed that the E1A binding protein p400 (EP400) was bound preferentially to and required for transcription stimulation by acetylated double-variant chromatin. EP400 also stimulated H2AZ/H3.3 deposition into promoters and enhancers and influenced transcription in vivo at a step downstream of the Mediator complex. EP400 efficiently exchanged recombinant histones H2A and H3.1 with H2AZ and H3.3, respectively, in a chromatin- and ATP-stimulated manner in vitro. Our data reveal that EP400 deposits H3.3 into chromatin alongside H2AZ and contributes to gene regulation after PIC assembly." @default.
- W2191719293 created "2016-06-24" @default.
- W2191719293 creator A5017931128 @default.
- W2191719293 creator A5019581784 @default.
- W2191719293 creator A5026752443 @default.
- W2191719293 creator A5034888711 @default.
- W2191719293 creator A5040925674 @default.
- W2191719293 creator A5060172979 @default.
- W2191719293 creator A5079634160 @default.
- W2191719293 creator A5090205225 @default.
- W2191719293 date "2016-01-01" @default.
- W2191719293 modified "2023-10-18" @default.
- W2191719293 title "EP400 Deposits H3.3 into Promoters and Enhancers during Gene Activation" @default.
- W2191719293 cites W1963851622 @default.
- W2191719293 cites W1965582387 @default.
- W2191719293 cites W1967011539 @default.
- W2191719293 cites W1968637358 @default.
- W2191719293 cites W1970916644 @default.
- W2191719293 cites W1983405576 @default.
- W2191719293 cites W1991045672 @default.
- W2191719293 cites W1993749620 @default.
- W2191719293 cites W1994222671 @default.
- W2191719293 cites W2000748839 @default.
- W2191719293 cites W2005575818 @default.
- W2191719293 cites W2006546441 @default.
- W2191719293 cites W2008284328 @default.
- W2191719293 cites W2008543992 @default.
- W2191719293 cites W2017964332 @default.
- W2191719293 cites W2018056726 @default.
- W2191719293 cites W2029388127 @default.
- W2191719293 cites W2037579319 @default.
- W2191719293 cites W2043789254 @default.
- W2191719293 cites W2043875696 @default.
- W2191719293 cites W2044312163 @default.
- W2191719293 cites W2047107109 @default.
- W2191719293 cites W2072364431 @default.
- W2191719293 cites W2073301405 @default.
- W2191719293 cites W2087573417 @default.
- W2191719293 cites W2088641994 @default.
- W2191719293 cites W2097065948 @default.
- W2191719293 cites W2097570538 @default.
- W2191719293 cites W2099054686 @default.
- W2191719293 cites W2099188975 @default.
- W2191719293 cites W2100600738 @default.
- W2191719293 cites W2109054128 @default.
- W2191719293 cites W2109315379 @default.
- W2191719293 cites W2110033136 @default.
- W2191719293 cites W2111578933 @default.
- W2191719293 cites W2113451554 @default.
- W2191719293 cites W2115988563 @default.
- W2191719293 cites W2118997256 @default.
- W2191719293 cites W2120948678 @default.
- W2191719293 cites W2122925985 @default.
- W2191719293 cites W2123460634 @default.
- W2191719293 cites W2124985265 @default.
- W2191719293 cites W2131543691 @default.
- W2191719293 cites W2133089130 @default.
- W2191719293 cites W2133452708 @default.
- W2191719293 cites W2136623765 @default.
- W2191719293 cites W2141458291 @default.
- W2191719293 cites W2141897899 @default.
- W2191719293 cites W2144706906 @default.
- W2191719293 cites W2146728902 @default.
- W2191719293 cites W2147690311 @default.
- W2191719293 cites W2149757771 @default.
- W2191719293 cites W2151108285 @default.
- W2191719293 cites W2158074192 @default.
- W2191719293 cites W2161183329 @default.
- W2191719293 cites W2162716784 @default.
- W2191719293 cites W2163591068 @default.
- W2191719293 cites W2163618254 @default.
- W2191719293 cites W2169640176 @default.
- W2191719293 doi "https://doi.org/10.1016/j.molcel.2015.10.039" @default.
- W2191719293 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4707986" @default.
- W2191719293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26669263" @default.
- W2191719293 hasPublicationYear "2016" @default.
- W2191719293 type Work @default.
- W2191719293 sameAs 2191719293 @default.
- W2191719293 citedByCount "87" @default.
- W2191719293 countsByYear W21917192932016 @default.
- W2191719293 countsByYear W21917192932017 @default.
- W2191719293 countsByYear W21917192932018 @default.
- W2191719293 countsByYear W21917192932019 @default.
- W2191719293 countsByYear W21917192932020 @default.
- W2191719293 countsByYear W21917192932021 @default.
- W2191719293 countsByYear W21917192932022 @default.
- W2191719293 countsByYear W21917192932023 @default.
- W2191719293 crossrefType "journal-article" @default.
- W2191719293 hasAuthorship W2191719293A5017931128 @default.
- W2191719293 hasAuthorship W2191719293A5019581784 @default.
- W2191719293 hasAuthorship W2191719293A5026752443 @default.
- W2191719293 hasAuthorship W2191719293A5034888711 @default.
- W2191719293 hasAuthorship W2191719293A5040925674 @default.
- W2191719293 hasAuthorship W2191719293A5060172979 @default.
- W2191719293 hasAuthorship W2191719293A5079634160 @default.
- W2191719293 hasAuthorship W2191719293A5090205225 @default.
- W2191719293 hasBestOaLocation W21917192931 @default.
- W2191719293 hasConcept C10058791 @default.