FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2191874436> ?p ?o ?g. }

• W2191874436 endingPage "77" @default.
• W2191874436 startingPage "69" @default.
• W2191874436 abstract "Recently, we have demonstrated that conditional inactivation of glucocorticoid receptors (GRs) in the noradrenergic system, may evoke depressive-like behavior in female but not male mutant mice (GR(DBHCre) mice). The aim of the current study was to dissect how selective ablation of glucocorticoid signaling in the noradrenergic system influences the previously reported depressive-like phenotype and whether it might be linked to neurotrophic alterations or secondary changes in the serotonergic system. We demonstrated that selective depletion of GRs enhances brain derived neurotrophic factor (BDNF) expression in female but not male GR(DBHCre) mice on both the mRNA and protein levels. The possible impact of the mutation on brain noradrenergic and serotonergic systems was addressed by investigating the tissue neurotransmitter levels under basal conditions and after acute restraint stress. The findings indicated a stress-provoked differential response in tissue noradrenaline content in the GR(DBHCre) female but not male mutant mice. An analogous gender-specific effect was identified in the diminished content of 5-hydroxyindoleacetic acid, the main metabolite of serotonin, in the prefrontal cortex, which suggests down-regulation of this monoamine system in female GR(DBHCre) mice. The lack of GR also resulted in an up-regulation of alpha2-adrenergic receptor (α2-AR) density in the female but not male mutants in the locus coeruleus. We have also confirmed the utility of the investigated model in pharmacological studies, which demonstrates that the depressive-like phenotype of GR(DBHCre) female mice can be reversed by antidepressant treatment with desipramine or fluoxetine, with the latter drug evoking more pronounced effects. Overall, our study validates the use of female GR(DBHCre) mice as an interesting and novel genetic tool for the investigation of the cross-connected mechanisms of depression that is not only based on behavioral phenotypes." @default.
• W2191874436 created "2016-06-24" @default.
• W2191874436 creator A5044363360 @default.
• W2191874436 creator A5046400387 @default.
• W2191874436 creator A5051298783 @default.
• W2191874436 creator A5068031858 @default.
• W2191874436 creator A5073568711 @default.
• W2191874436 creator A5075074462 @default.
• W2191874436 creator A5075539717 @default.
• W2191874436 creator A5080760272 @default.
• W2191874436 date "2015-10-01" @default.
• W2191874436 modified "2023-10-17" @default.
• W2191874436 title "Disruption of glucocorticoid receptors in the noradrenergic system leads to BDNF up-regulation and altered serotonergic transmission associated with a depressive-like phenotype in female GRDBHCre mice" @default.
• W2191874436 cites W1481790816 @default.
• W2191874436 cites W166919779 @default.
• W2191874436 cites W1965366182 @default.
• W2191874436 cites W1965641144 @default.
• W2191874436 cites W1971880874 @default.
• W2191874436 cites W1977611961 @default.
• W2191874436 cites W1981064419 @default.
• W2191874436 cites W1983548799 @default.
• W2191874436 cites W1989072873 @default.
• W2191874436 cites W1990663212 @default.
• W2191874436 cites W1991436104 @default.
• W2191874436 cites W1995441711 @default.
• W2191874436 cites W1996201882 @default.
• W2191874436 cites W1998143129 @default.
• W2191874436 cites W2000793737 @default.
• W2191874436 cites W2001946273 @default.
• W2191874436 cites W2002335998 @default.
• W2191874436 cites W2009500374 @default.
• W2191874436 cites W2009792683 @default.
• W2191874436 cites W2010269783 @default.
• W2191874436 cites W2012353464 @default.
• W2191874436 cites W2013455001 @default.
• W2191874436 cites W2019284117 @default.
• W2191874436 cites W2022387887 @default.
• W2191874436 cites W2025682675 @default.
• W2191874436 cites W2026081258 @default.
• W2191874436 cites W2028625863 @default.
• W2191874436 cites W2028628723 @default.
• W2191874436 cites W2029887922 @default.
• W2191874436 cites W2034189826 @default.
• W2191874436 cites W2035266273 @default.
• W2191874436 cites W2037050842 @default.
• W2191874436 cites W2037111632 @default.
• W2191874436 cites W2041378955 @default.
• W2191874436 cites W2048076151 @default.
• W2191874436 cites W2049036348 @default.
• W2191874436 cites W2049154282 @default.
• W2191874436 cites W2050069080 @default.
• W2191874436 cites W2050091356 @default.
• W2191874436 cites W2052737201 @default.
• W2191874436 cites W2053192285 @default.
• W2191874436 cites W2053624500 @default.
• W2191874436 cites W2053655390 @default.
• W2191874436 cites W2055747883 @default.
• W2191874436 cites W2060401891 @default.
• W2191874436 cites W2066503873 @default.
• W2191874436 cites W2067210690 @default.
• W2191874436 cites W2067815532 @default.
• W2191874436 cites W2070058327 @default.
• W2191874436 cites W2071887266 @default.
• W2191874436 cites W2075609074 @default.
• W2191874436 cites W2077060635 @default.
• W2191874436 cites W2077320328 @default.
• W2191874436 cites W2089198034 @default.
• W2191874436 cites W2091376366 @default.
• W2191874436 cites W2103860332 @default.
• W2191874436 cites W2110696099 @default.
• W2191874436 cites W2111626297 @default.
• W2191874436 cites W2117345428 @default.
• W2191874436 cites W2121403816 @default.
• W2191874436 cites W2121651624 @default.
• W2191874436 cites W2130685024 @default.
• W2191874436 cites W2139110700 @default.
• W2191874436 cites W2141092265 @default.
• W2191874436 cites W2147289447 @default.
• W2191874436 cites W2150348173 @default.
• W2191874436 cites W2153411651 @default.
• W2191874436 cites W2154490963 @default.
• W2191874436 cites W2168675611 @default.
• W2191874436 doi "https://doi.org/10.1016/j.pbb.2015.08.001" @default.
• W2191874436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26261018" @default.
• W2191874436 hasPublicationYear "2015" @default.
• W2191874436 type Work @default.
• W2191874436 sameAs 2191874436 @default.
• W2191874436 citedByCount "11" @default.
• W2191874436 countsByYear W21918744362016 @default.
• W2191874436 countsByYear W21918744362017 @default.
• W2191874436 countsByYear W21918744362018 @default.
• W2191874436 countsByYear W21918744362019 @default.
• W2191874436 countsByYear W21918744362020 @default.
• W2191874436 countsByYear W21918744362022 @default.
• W2191874436 crossrefType "journal-article" @default.
• W2191874436 hasAuthorship W2191874436A5044363360 @default.
• W2191874436 hasAuthorship W2191874436A5046400387 @default.
• W2191874436 hasAuthorship W2191874436A5051298783 @default.

• next