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• W2191930222 abstract "Tranexamic acid (4-aminomethyl-cyclohexanecarboxylic acid) was reacted with sulfonyl chlorides to produce structurally related four sulfonamide derivatives using simple and environmental friendly method to check out their three-dimensional behavior and van der Walls interactions. The molecules were crystallized in different possibilities, as it is/after alkylation at its O and N atoms/along with a co-molecule. All molecules were crystallized in monoclinic crystal system with space group P21/n, P21/c and P21/a. X-ray studies reveal that the molecules stabilized themselves by different kinds of hydrogen bonding interactions. The molecules are getting connected through O–H⋯O hydrogen bonds to form inversion dimers which are further connected through N–H⋯O interactions. The molecules in which N and O atoms were alkylated showed non-classical interaction and generated centro-symmetric R22(24) ring motif. The co-crystallized host and guest molecules are connected to each other via O–H⋯O interactions to generate different ring motifs. By means of the ToposPro software an analysis of the topologies of underlying nets that correspond to molecular packings and hydrogen-bonded networks in structures under consideration was carried out." @default.
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• W2191930222 date "2016-01-01" @default.
• W2191930222 modified "2023-09-23" @default.
• W2191930222 title "Synthesis and description of intermolecular interactions in new sulfonamide derivatives of tranexamic acid" @default.
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• W2191930222 doi "https://doi.org/10.1016/j.molstruc.2015.09.022" @default.
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