FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W219212900> ?p ?o ?g. }

• W219212900 endingPage "1351" @default.
• W219212900 startingPage "1345" @default.
• W219212900 abstract "We have previously shown that the gene for variant surface glycoprotein 118 of Trypanosoma brucei (strain 427) is activated by a duplicative transposition to a telomeric expression site. In chronically-infected animals, this expression-linked copy is lost when the 118 gene is replaced at the expression site by another variant surface glycoprotein gene. We show here that expression of the 118 gene can also be switched off without loss of the extra expression-linked copy. In two variants, called 1.8b and 1.8c, we find expression of the variant surface glycoprotein 1.8 gene, notwithstanding the continued presence of the 118 expression-linked copy. The 1.8 gene activated has a telomeric location, like the 118 expression-linked copy. In variant 1.8b, activation is accompanied by duplication of the 1.8 gene, resulting in an extra telomeric gene copy; in variant 1.8c it is not. Variants 1.8b and 1.8c both switch back preferentially to expression of the 118 gene. The 5'-flanking regions of the active, inactive and reactivated versions of the 118 expression-linked copy are indistinguishable by restriction mapping up to 28 kb. We conclude that there are at least two separate telomeric expression sites in our T. brucei strain. How these are switched on and off is unclear. The ability to retain expression-linked copies in inactive form may allow the trypanosome to re-programme the order in which variant surface glycoprotein genes are expressed." @default.
• W219212900 created "2016-06-24" @default.
• W219212900 creator A5009940288 @default.
• W219212900 creator A5010885639 @default.
• W219212900 creator A5060054431 @default.
• W219212900 creator A5087388921 @default.
• W219212900 date "1984-06-01" @default.
• W219212900 modified "2023-10-16" @default.
• W219212900 title "The inactivation and reactivation of an expression-linked gene copy for a variant surface glycoprotein in Trypanosoma brucei." @default.
• W219212900 cites W1544719229 @default.
• W219212900 cites W1965243112 @default.
• W219212900 cites W1966107128 @default.
• W219212900 cites W1971840298 @default.
• W219212900 cites W1974299317 @default.
• W219212900 cites W1982191605 @default.
• W219212900 cites W1983045028 @default.
• W219212900 cites W1989648583 @default.
• W219212900 cites W1995084605 @default.
• W219212900 cites W2003352045 @default.
• W219212900 cites W2007211785 @default.
• W219212900 cites W2009828593 @default.
• W219212900 cites W2015315658 @default.
• W219212900 cites W2016998805 @default.
• W219212900 cites W2029987769 @default.
• W219212900 cites W2034693195 @default.
• W219212900 cites W2036122175 @default.
• W219212900 cites W2036730675 @default.
• W219212900 cites W2051057409 @default.
• W219212900 cites W2052509370 @default.
• W219212900 cites W2059559858 @default.
• W219212900 cites W2063450941 @default.
• W219212900 cites W2068417020 @default.
• W219212900 cites W2068835891 @default.
• W219212900 cites W2069736599 @default.
• W219212900 cites W2070699090 @default.
• W219212900 cites W2073329016 @default.
• W219212900 cites W2075153485 @default.
• W219212900 cites W2077077811 @default.
• W219212900 cites W2079254989 @default.
• W219212900 cites W2080255571 @default.
• W219212900 cites W2085287282 @default.
• W219212900 cites W2098790794 @default.
• W219212900 cites W2099200936 @default.
• W219212900 cites W2131655462 @default.
• W219212900 cites W2135602522 @default.
• W219212900 cites W2143381397 @default.
• W219212900 cites W2163043252 @default.
• W219212900 cites W2163673908 @default.
• W219212900 cites W2167125851 @default.
• W219212900 cites W2327885772 @default.
• W219212900 cites W2400347555 @default.
• W219212900 cites W980329056 @default.
• W219212900 doi "https://doi.org/10.1002/j.1460-2075.1984.tb01975.x" @default.
• W219212900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/557521" @default.
• W219212900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6086319" @default.
• W219212900 hasPublicationYear "1984" @default.
• W219212900 type Work @default.
• W219212900 sameAs 219212900 @default.
• W219212900 citedByCount "78" @default.
• W219212900 countsByYear W2192129002015 @default.
• W219212900 countsByYear W2192129002016 @default.
• W219212900 countsByYear W2192129002017 @default.
• W219212900 countsByYear W2192129002018 @default.
• W219212900 countsByYear W2192129002022 @default.
• W219212900 crossrefType "journal-article" @default.
• W219212900 hasAuthorship W219212900A5009940288 @default.
• W219212900 hasAuthorship W219212900A5010885639 @default.
• W219212900 hasAuthorship W219212900A5060054431 @default.
• W219212900 hasAuthorship W219212900A5087388921 @default.
• W219212900 hasBestOaLocation W2192129001 @default.
• W219212900 hasConcept C104317684 @default.
• W219212900 hasConcept C150194340 @default.
• W219212900 hasConcept C153911025 @default.
• W219212900 hasConcept C165864922 @default.
• W219212900 hasConcept C2779502636 @default.
• W219212900 hasConcept C54355233 @default.
• W219212900 hasConcept C7602840 @default.
• W219212900 hasConcept C86803240 @default.
• W219212900 hasConceptScore W219212900C104317684 @default.
• W219212900 hasConceptScore W219212900C150194340 @default.
• W219212900 hasConceptScore W219212900C153911025 @default.
• W219212900 hasConceptScore W219212900C165864922 @default.
• W219212900 hasConceptScore W219212900C2779502636 @default.
• W219212900 hasConceptScore W219212900C54355233 @default.
• W219212900 hasConceptScore W219212900C7602840 @default.
• W219212900 hasConceptScore W219212900C86803240 @default.
• W219212900 hasIssue "6" @default.
• W219212900 hasLocation W2192129001 @default.
• W219212900 hasLocation W2192129002 @default.
• W219212900 hasLocation W2192129003 @default.
• W219212900 hasOpenAccess W219212900 @default.
• W219212900 hasPrimaryLocation W2192129001 @default.
• W219212900 hasRelatedWork W1971323496 @default.
• W219212900 hasRelatedWork W1979124359 @default.
• W219212900 hasRelatedWork W1988452225 @default.
• W219212900 hasRelatedWork W1995867836 @default.
• W219212900 hasRelatedWork W2043199743 @default.
• W219212900 hasRelatedWork W2111721589 @default.

• next