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- W2192139417 abstract "Psychiatric and neurodegenerative disorders, such as autism spectrum disorders (ASDs), schizophrenia (SZ), and Alzheimer's disease (AD), pose an immense burden to society. While significant progress has been made in recent years toward understanding the genetic architecture, cellular substrates, brain circuits, and endophenotypes of these disorders, we are still far from being able to treat and prevent these disorders effectively. Genetic, functional imaging, postmortem neuropathological, and pharmacological evidence implicate spiny synapses as key substrates of pathogenesis in ASD, SZ, and AD. Although alterations in dendritic spines, the sites of glutamatergic communication between neurons in the brain, are certainly not the only abnormalities in the brain that are relevant for these diseases, understanding the molecular underpinnings of dendritic spine pathology may provide essential insight into the pathogenesis of these disorders, and can reveal novel drug targets to treat them. In this chapter, we will discuss recent neuropathological, genetic, animal model, and molecular studies that implicate structural alterations at spiny synapses in the pathogenesis of major psychiatric and neurodegenerative disorders, including ASD, SZ, and AD." @default.
- W2192139417 created "2016-06-24" @default.
- W2192139417 creator A5029281832 @default.
- W2192139417 creator A5040981992 @default.
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- W2192139417 creator A5057312365 @default.
- W2192139417 creator A5059938833 @default.
- W2192139417 creator A5071692996 @default.
- W2192139417 date "2014-01-01" @default.
- W2192139417 modified "2023-09-25" @default.
- W2192139417 title "Structural Alterations of Synapses in Psychiatric and Neurodegenerative Disorders" @default.
- W2192139417 cites W1514559719 @default.
- W2192139417 cites W1885585690 @default.
- W2192139417 cites W189747386 @default.
- W2192139417 cites W1965543302 @default.
- W2192139417 cites W1968198840 @default.
- W2192139417 cites W1969409914 @default.
- W2192139417 cites W1971321176 @default.
- W2192139417 cites W1971624220 @default.
- W2192139417 cites W1972260406 @default.
- W2192139417 cites W1972334605 @default.
- W2192139417 cites W1972471050 @default.
- W2192139417 cites W1976358763 @default.
- W2192139417 cites W1977197102 @default.
- W2192139417 cites W1977390447 @default.
- W2192139417 cites W1977617725 @default.
- W2192139417 cites W1980073907 @default.
- W2192139417 cites W1980750700 @default.
- W2192139417 cites W1982142913 @default.
- W2192139417 cites W1983194657 @default.
- W2192139417 cites W1984899161 @default.
- W2192139417 cites W1984924722 @default.
- W2192139417 cites W1985086842 @default.
- W2192139417 cites W1986563644 @default.
- W2192139417 cites W1987095222 @default.
- W2192139417 cites W1989278867 @default.
- W2192139417 cites W1990752558 @default.
- W2192139417 cites W1991721037 @default.
- W2192139417 cites W1993124121 @default.
- W2192139417 cites W1993465897 @default.
- W2192139417 cites W1993755985 @default.
- W2192139417 cites W1994517931 @default.
- W2192139417 cites W1996092810 @default.
- W2192139417 cites W1998944144 @default.
- W2192139417 cites W1999775510 @default.
- W2192139417 cites W2001210466 @default.
- W2192139417 cites W2001528712 @default.
- W2192139417 cites W2001630973 @default.
- W2192139417 cites W2002012536 @default.
- W2192139417 cites W2004451728 @default.
- W2192139417 cites W2008767130 @default.
- W2192139417 cites W2009262775 @default.
- W2192139417 cites W2013553668 @default.
- W2192139417 cites W2014141616 @default.
- W2192139417 cites W2015588918 @default.
- W2192139417 cites W2015933608 @default.
- W2192139417 cites W2016717347 @default.
- W2192139417 cites W2017097994 @default.
- W2192139417 cites W2018342879 @default.
- W2192139417 cites W2020486984 @default.
- W2192139417 cites W2021996855 @default.
- W2192139417 cites W2025561374 @default.
- W2192139417 cites W2027704676 @default.
- W2192139417 cites W2029037348 @default.
- W2192139417 cites W2034424952 @default.
- W2192139417 cites W2038661578 @default.
- W2192139417 cites W2041794412 @default.
- W2192139417 cites W2046948258 @default.
- W2192139417 cites W2048571739 @default.
- W2192139417 cites W2057178460 @default.
- W2192139417 cites W2057308155 @default.
- W2192139417 cites W2059890547 @default.
- W2192139417 cites W2061684042 @default.
- W2192139417 cites W2062317659 @default.
- W2192139417 cites W2062335102 @default.
- W2192139417 cites W2062416387 @default.
- W2192139417 cites W2064452627 @default.
- W2192139417 cites W2064702750 @default.
- W2192139417 cites W2071482305 @default.
- W2192139417 cites W2074078151 @default.
- W2192139417 cites W2074791552 @default.
- W2192139417 cites W2075779454 @default.
- W2192139417 cites W2082151254 @default.
- W2192139417 cites W2083062984 @default.
- W2192139417 cites W2083752135 @default.
- W2192139417 cites W2084889756 @default.
- W2192139417 cites W2088937623 @default.
- W2192139417 cites W2089741501 @default.
- W2192139417 cites W2090025294 @default.
- W2192139417 cites W2091612053 @default.
- W2192139417 cites W2092315684 @default.
- W2192139417 cites W2095119525 @default.
- W2192139417 cites W2097088842 @default.
- W2192139417 cites W2099610622 @default.
- W2192139417 cites W2102837197 @default.
- W2192139417 cites W2103189755 @default.
- W2192139417 cites W2111683208 @default.
- W2192139417 cites W2112990976 @default.