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- W2192155495 abstract "This chapter discusses the inhibitory effect of 2-deoxy-D-glucose on Fc and third component of complement (C3b) receptor-mediated phagocytosis in phagocytic cells. The ability to phagocytize particulate materials is a function of many mammalian cells. Macrophages contain on their plasma membranes receptors for these ligands, the cleaved C3b and the Fc portion of immunoglobulin G (IgG). The ingestion of immunoglobulin G- or complement-coated particles proceeds by the sequential and circumferential interaction of these ligands with the Fc or complement receptors on the plasma membrane of the phagocyte. The ultrastructural examination of these preparations verified that the ingested lymphocytes were diffusely coated with anti-immunoglobulin that was labeled with the enzyme peroxidase to form an electron-dense reaction product. 2-Deoxy-D-glucose inhibits the phagocytosis of immunoglobulin G, or complement-coated sheep erythrocytes by mouse peritoneal macrophages, but does not inhibit the phagocytosis of latex or zymosan particles by the same cells. The capacity of 2-deoxy-O-glucose-treated macrophages to ingest latex and zymosan particles indicates that 2-deoxy-O-glucose does not have a toxic effect on the ingestion process." @default.
- W2192155495 created "2016-06-24" @default.
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- W2192155495 date "1978-01-01" @default.
- W2192155495 modified "2023-09-27" @default.
- W2192155495 title "THE INHIBITORY EFFECT OF 2-DEOXY-D-GLUCOSE ON Fc AND C3b RECEPTOR-MEDIATED PHAGOCYTOSIS IN PHAGOCYTIC CELLS11Supported by Grant AI 08697 from the U.S. Public Health Service." @default.
- W2192155495 doi "https://doi.org/10.1016/b978-0-12-636150-6.50039-8" @default.
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