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• W2192184313 abstract "Abstract Introduction Systemic delivery of bone marrow-derived mesenchymal stem cells (MSC) seems to be of benefit in the treatment of multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS) sustained by migration of T cells across the brain blood barrier (BBB) and subsequent induction of inflammatory lesions into CNS. MSC have been found to modulate several effector functions of T cells. In this study, we investigated the effects of MSC on adhesion molecules and receptors on T cell surface that sustain their transendothelial migration. Methods We used different co-culture methods combined with real-time PCR and flow cytometry to evaluate the expression both at the mRNA and at the plasma-membrane level of α4 integrin, β2 integrin, ICAM-1 and CXCR3. In parallel, we assessed if MSC are able to modulate expression of adhesion molecules on the endothelial cells that interact with T cells during their transendothelial migration. Results Our in vitro analyses revealed that MSC: (i) inhibit proliferation and activation of both peripheral blood mononuclear cells (PBMC) and CD3 + -selected lymphocytes through the release of soluble factors; (ii) exert suppressive effects on those surface molecules highly expressed by activated lymphocytes and involved in transendothelial migration; (iii) inhibit CXCL10-driven chemotaxis of CD3 + cells; (iv) down-regulated expression of adhesion molecules on endothelial cells. Conclusions Taken together, these data demonstrate that the immunosuppressive effect of MSC does not exclusively depends on their anti-proliferative activity on T cells, but also on the impairment of leukocyte migratory potential through the inhibition of the adhesion molecules and receptors that are responsible for T cell trafficking across BBB. This could suggest a new mechanism through which MSC modulate T cell responses." @default.
• W2192184313 created "2016-06-24" @default.
• W2192184313 creator A5028436351 @default.
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• W2192184313 date "2015-12-01" @default.
• W2192184313 modified "2023-10-02" @default.
• W2192184313 title "Human mesenchymal stem cells target adhesion molecules and receptors involved in T cell extravasation" @default.
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• W2192184313 doi "https://doi.org/10.1186/s13287-015-0222-y" @default.
• W2192184313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4676115" @default.
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• W2192184313 hasPublicationYear "2015" @default.
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