Matches in SemOpenAlex for { <https://semopenalex.org/work/W2192215274> ?p ?o ?g. }
- W2192215274 abstract "T cell memory plays a critical role in our protection against pathogens and tumors. The antigen and its interaction with the T cell receptor (TCR) is one of the initiating elements that shape T cell memory together with inflammation and costimulation. Over the last decade several transcription factors and signaling pathways that support memory programming have been identified. However, how TCR signals regulate them is still poorly understood. Recent studies have shown that the biochemical rules that govern T cell memory, strikingly, change depending on TCR signal strength. Furthermore, TCR signal strength regulates the input of cytokine signaling, including pro-inflammatory cytokines. These highlight how tailoring antigenic signals can improve immune therapeutics. In this review, we focus on how TCR signaling regulates T cell memory and how the quantity and quality of TCR-peptide-MHC interactions impact the multiple fates a T cell can adopt in the memory pool." @default.
- W2192215274 created "2016-06-24" @default.
- W2192215274 creator A5029969059 @default.
- W2192215274 creator A5070906167 @default.
- W2192215274 date "2015-12-10" @default.
- W2192215274 modified "2023-10-01" @default.
- W2192215274 title "TCR Signaling in T Cell Memory" @default.
- W2192215274 cites W1524506477 @default.
- W2192215274 cites W1535972616 @default.
- W2192215274 cites W1541097619 @default.
- W2192215274 cites W1541571439 @default.
- W2192215274 cites W1547165466 @default.
- W2192215274 cites W1567351976 @default.
- W2192215274 cites W1598201397 @default.
- W2192215274 cites W1618234411 @default.
- W2192215274 cites W1753980905 @default.
- W2192215274 cites W1781304070 @default.
- W2192215274 cites W1792798728 @default.
- W2192215274 cites W1839632455 @default.
- W2192215274 cites W1940920642 @default.
- W2192215274 cites W1958291094 @default.
- W2192215274 cites W1965464730 @default.
- W2192215274 cites W1966047059 @default.
- W2192215274 cites W1966823977 @default.
- W2192215274 cites W1966862330 @default.
- W2192215274 cites W1967261754 @default.
- W2192215274 cites W1967662656 @default.
- W2192215274 cites W1969031853 @default.
- W2192215274 cites W1969950015 @default.
- W2192215274 cites W1970181089 @default.
- W2192215274 cites W1971806373 @default.
- W2192215274 cites W1973601490 @default.
- W2192215274 cites W1982704558 @default.
- W2192215274 cites W1985360468 @default.
- W2192215274 cites W1986189485 @default.
- W2192215274 cites W1992267675 @default.
- W2192215274 cites W1994500716 @default.
- W2192215274 cites W1996229570 @default.
- W2192215274 cites W1996483176 @default.
- W2192215274 cites W1998856404 @default.
- W2192215274 cites W1999324987 @default.
- W2192215274 cites W1999430932 @default.
- W2192215274 cites W2002541767 @default.
- W2192215274 cites W2006435611 @default.
- W2192215274 cites W2008366157 @default.
- W2192215274 cites W2008403890 @default.
- W2192215274 cites W2009499556 @default.
- W2192215274 cites W2009557891 @default.
- W2192215274 cites W2009854316 @default.
- W2192215274 cites W2010234200 @default.
- W2192215274 cites W2014034870 @default.
- W2192215274 cites W2017037510 @default.
- W2192215274 cites W2017176455 @default.
- W2192215274 cites W2018476626 @default.
- W2192215274 cites W2018553282 @default.
- W2192215274 cites W2023396531 @default.
- W2192215274 cites W2025195484 @default.
- W2192215274 cites W2026932044 @default.
- W2192215274 cites W2031967183 @default.
- W2192215274 cites W2037751912 @default.
- W2192215274 cites W2039565814 @default.
- W2192215274 cites W2041314367 @default.
- W2192215274 cites W2043793366 @default.
- W2192215274 cites W2046700010 @default.
- W2192215274 cites W2048815304 @default.
- W2192215274 cites W2056100438 @default.
- W2192215274 cites W2058158581 @default.
- W2192215274 cites W2058634008 @default.
- W2192215274 cites W2059689009 @default.
- W2192215274 cites W2060513670 @default.
- W2192215274 cites W2060530677 @default.
- W2192215274 cites W2064625208 @default.
- W2192215274 cites W2065755680 @default.
- W2192215274 cites W2067064730 @default.
- W2192215274 cites W2067419830 @default.
- W2192215274 cites W2067939508 @default.
- W2192215274 cites W2069271524 @default.
- W2192215274 cites W2070530924 @default.
- W2192215274 cites W2071548401 @default.
- W2192215274 cites W2073655356 @default.
- W2192215274 cites W2078262203 @default.
- W2192215274 cites W2078956671 @default.
- W2192215274 cites W2084253027 @default.
- W2192215274 cites W2089497292 @default.
- W2192215274 cites W2091049770 @default.
- W2192215274 cites W2091218020 @default.
- W2192215274 cites W2091954081 @default.
- W2192215274 cites W2095705567 @default.
- W2192215274 cites W2095881540 @default.
- W2192215274 cites W2097100932 @default.
- W2192215274 cites W2097336904 @default.
- W2192215274 cites W2099295104 @default.
- W2192215274 cites W2100412095 @default.
- W2192215274 cites W2100778289 @default.
- W2192215274 cites W2102950218 @default.
- W2192215274 cites W2106166533 @default.
- W2192215274 cites W2107243002 @default.
- W2192215274 cites W2111300838 @default.
- W2192215274 cites W2114651496 @default.
- W2192215274 cites W2115082024 @default.