FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2192237899> ?p ?o ?g. }

• W2192237899 endingPage "122" @default.
• W2192237899 startingPage "112" @default.
• W2192237899 abstract "Objective: The goals of the research were to determine if a foamy effect on macrophages was due to human endogenous retrovirus K102 (HERV-K102) replication, and to further address its potential significance in HIV-1 infection. Methods: An RT-PCR HERV-K HML-2 pol method was used to screen the unknown HERV, and isolated bands were sent for sequencing. Confirmation of RNA expression was performed by a real time quantitative PCR (qPCR) pol ddCt method. Rabbit antibodies to Env peptides were used to assess expression by immunohistology and processing of Env by western blots. A qPCR pol ddCt method to ascertain genomic copy number was performed on genomic DNA isolated from plasma comparing HIV-1 exposed seronegative (HESN) commercial sex workers (CSW) to normal controls and contrasted with HIV-1 patients. Results: HERV-K102 expression, particle production and replication were associated with foamy macrophage generation in the cultures of cord blood mononuclear cells under permissive conditions. A five-fold increased HERV-K102 pol genomic copy number was found in the HESN cohort over normal which was not found in HIV-1 positive patients (p=0.0005). Conclusions: This work extends the evidence that HERV-K102 has foamy virus attributes, is replication competent, and is capable of high replication rate in vivo and in vitro. This may be the first characterization of a replication-competent, foamy-like virus of humans. High particle production inferred by increased integration in the HESN cohort over HIV-1 patients raises the issue of the clinical importance of HERV-K102 particle production as an early protective innate immune response against HIV-1 replication." @default.
• W2192237899 created "2016-06-24" @default.
• W2192237899 creator A5011838824 @default.
• W2192237899 creator A5013042494 @default.
• W2192237899 creator A5017186738 @default.
• W2192237899 creator A5090162954 @default.
• W2192237899 date "2015-12-08" @default.
• W2192237899 modified "2023-09-27" @default.
• W2192237899 title "Further Evidence that Human Endogenous Retrovirus K102 is a Replication Competent Foamy Virus that may Antagonize HIV-1 Replication" @default.
• W2192237899 cites W132604487 @default.
• W2192237899 cites W1514509695 @default.
• W2192237899 cites W166593606 @default.
• W2192237899 cites W1976841728 @default.
• W2192237899 cites W1981854282 @default.
• W2192237899 cites W1983262897 @default.
• W2192237899 cites W1984890118 @default.
• W2192237899 cites W1985478156 @default.
• W2192237899 cites W2000744943 @default.
• W2192237899 cites W2001079898 @default.
• W2192237899 cites W2023851657 @default.
• W2192237899 cites W2037629038 @default.
• W2192237899 cites W2038340694 @default.
• W2192237899 cites W2057470167 @default.
• W2192237899 cites W2057519261 @default.
• W2192237899 cites W2063547657 @default.
• W2192237899 cites W2063701006 @default.
• W2192237899 cites W2066121768 @default.
• W2192237899 cites W2078066011 @default.
• W2192237899 cites W2080500668 @default.
• W2192237899 cites W2082922487 @default.
• W2192237899 cites W2083354792 @default.
• W2192237899 cites W2097433834 @default.
• W2192237899 cites W2097745684 @default.
• W2192237899 cites W2103367520 @default.
• W2192237899 cites W2106431826 @default.
• W2192237899 cites W2107548027 @default.
• W2192237899 cites W2108894254 @default.
• W2192237899 cites W2109358132 @default.
• W2192237899 cites W2114655112 @default.
• W2192237899 cites W2118058327 @default.
• W2192237899 cites W2120463956 @default.
• W2192237899 cites W2121876768 @default.
• W2192237899 cites W2125586839 @default.
• W2192237899 cites W2133426611 @default.
• W2192237899 cites W2133945524 @default.
• W2192237899 cites W2140258750 @default.
• W2192237899 cites W2141488802 @default.
• W2192237899 cites W2145385317 @default.
• W2192237899 cites W2149317992 @default.
• W2192237899 cites W2149525857 @default.
• W2192237899 cites W2149623947 @default.
• W2192237899 cites W2156270683 @default.
• W2192237899 cites W2314241692 @default.
• W2192237899 doi "https://doi.org/10.2174/1874613601509010112" @default.
• W2192237899 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4714383" @default.
• W2192237899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26793281" @default.
• W2192237899 hasPublicationYear "2015" @default.
• W2192237899 type Work @default.
• W2192237899 sameAs 2192237899 @default.
• W2192237899 citedByCount "12" @default.
• W2192237899 countsByYear W21922378992017 @default.
• W2192237899 countsByYear W21922378992018 @default.
• W2192237899 countsByYear W21922378992019 @default.
• W2192237899 countsByYear W21922378992020 @default.
• W2192237899 countsByYear W21922378992021 @default.
• W2192237899 countsByYear W21922378992022 @default.
• W2192237899 countsByYear W21922378992023 @default.
• W2192237899 crossrefType "journal-article" @default.
• W2192237899 hasAuthorship W2192237899A5011838824 @default.
• W2192237899 hasAuthorship W2192237899A5013042494 @default.
• W2192237899 hasAuthorship W2192237899A5017186738 @default.
• W2192237899 hasAuthorship W2192237899A5090162954 @default.
• W2192237899 hasBestOaLocation W21922378992 @default.
• W2192237899 hasConcept C104317684 @default.
• W2192237899 hasConcept C121346293 @default.
• W2192237899 hasConcept C12590798 @default.
• W2192237899 hasConcept C134018914 @default.
• W2192237899 hasConcept C137061746 @default.
• W2192237899 hasConcept C140704245 @default.
• W2192237899 hasConcept C141231307 @default.
• W2192237899 hasConcept C159047783 @default.
• W2192237899 hasConcept C16613235 @default.
• W2192237899 hasConcept C202751555 @default.
• W2192237899 hasConcept C2522874641 @default.
• W2192237899 hasConcept C2778431562 @default.
• W2192237899 hasConcept C48023723 @default.
• W2192237899 hasConcept C54355233 @default.
• W2192237899 hasConcept C71924100 @default.
• W2192237899 hasConcept C86803240 @default.
• W2192237899 hasConceptScore W2192237899C104317684 @default.
• W2192237899 hasConceptScore W2192237899C121346293 @default.
• W2192237899 hasConceptScore W2192237899C12590798 @default.
• W2192237899 hasConceptScore W2192237899C134018914 @default.
• W2192237899 hasConceptScore W2192237899C137061746 @default.
• W2192237899 hasConceptScore W2192237899C140704245 @default.
• W2192237899 hasConceptScore W2192237899C141231307 @default.
• W2192237899 hasConceptScore W2192237899C159047783 @default.
• W2192237899 hasConceptScore W2192237899C16613235 @default.

• next