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- W2192263172 abstract "Summary B acillus thuringiensis subsp. israelensis ( B ti) is a natural pathogen of dipterans widely used as a biological insecticide for mosquito control. To characterize the response of mosquitoes to intoxication with B ti, the transcriptome profile of B ti‐exposed susceptible A edes aegypti larvae was analysed using I llumina RNA ‐seq. Gene expression of 11 alkaline phosphatases ( ALPs ) was further investigated by real time quantitative polymerase chain reaction and ALP activity was measured in the susceptible strain and in four strains resistant to a single B ti C ry toxin or to B ti. These strains were unexposed or exposed to their toxin of selection. Although all resistant strains constitutively exhibited a higher level of transcription of ALP genes than the susceptible strain, they showed a lower total ALP activity. The intoxication with different individual C ry toxins triggered a global pattern of ALP gene under‐transcription in all the one‐toxin‐resistant strains but involving different specific sets of ALPs in each resistant phenotype. Most of the ALPs involved are not known C ry‐binding proteins. RNA interference experiment demonstrated that reducing ALP expression conferred increased the survival of larvae exposed to Cry4Aa , confirming the involvement of ALP in Cry4Aa toxicity." @default.
- W2192263172 created "2016-06-24" @default.
- W2192263172 creator A5010638951 @default.
- W2192263172 creator A5017715950 @default.
- W2192263172 creator A5072490230 @default.
- W2192263172 creator A5081767080 @default.
- W2192263172 date "2016-01-21" @default.
- W2192263172 modified "2023-10-12" @default.
- W2192263172 title "Alkaline phosphatases are involved in the response of<i>A</i><i>edes aegypti</i>larvae to intoxication with<i>B</i><i>acillus thuringiensis</i>subsp.<i>israelensis</i> Cry toxins" @default.
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- W2192263172 doi "https://doi.org/10.1111/1462-2920.13186" @default.
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