Matches in SemOpenAlex for { <https://semopenalex.org/work/W2192294493> ?p ?o ?g. }
- W2192294493 abstract "Publisher Summary Alkaline phosphatase is a nonspecific phosphomonoester hydrolase widely found in prokaryotes, invertebrates, and higher animals; plants, though rich in nonspecific acid phosphatase activity, are not replete in alkaline phosphatase. The enzyme has long been recognized in mammals because of its ready detection even in whole tissue preparations by virtue of its high activity at alkaline pH (example, pH 10). In mammals, alkaline phosphatase is an essential, tissue-specific, membrane-associated enzyme. It is required for the deposition of calcium phosphate as hydroxyapatite in bone. The proliferating zone of epiphyseal plates is the richest source of alkaline phosphatase in bone. The enzyme has been implicated in the accumulation of calcium and phosphate by matrix vesicles where it is attached to the membranes of those vesicles. In the disease hypophosphatasia, because of a mutation in the structural gene for bone alkaline phosphatase, humans are deficient in this enzyme and show poor ossification and bone development." @default.
- W2192294493 created "2016-06-24" @default.
- W2192294493 creator A5038337581 @default.
- W2192294493 creator A5062609112 @default.
- W2192294493 date "1987-01-01" @default.
- W2192294493 modified "2023-10-05" @default.
- W2192294493 title "Chapter 8 Phosphomonoesterases" @default.
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