FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2192337112> ?p ?o ?g. }

• W2192337112 endingPage "221" @default.
• W2192337112 startingPage "211" @default.
• W2192337112 abstract "Melatonin is involved in the regulation of hippocampal neuronal development during adulthood. Emerging evidence indicates that exogenous melatonin acts during different events of the neurogenic process and exerts antidepressant-like behavior in rodents. Thus, melatonin might act through different mechanism, including acting as an antioxidant, interacting with intracellular proteins and/or activating membrane receptors. The melatonin membrane receptors (MMRs; Mt1/Mt2) are distributed throughout the hippocampus with an interesting localization in the hippocampal neurogenic microenvironment (niche), suggesting the involvement of these receptors in the beneficial effects of melatonin on hippocampal neurogenesis and behavior. In this study, we analyzed the participation of MMRs in the baseline neurogenesis in C57BL/6 mice. To this end, we used a pharmacological approach, administering luzindole (10 mg/kg) for 14 days. We observed a decrease in the absolute number of doublecortin-positive cells (49%) without changes in either the dendrite complexity of mature doublecortin-cells or the number of apoptotic cells (TUNEL). However, after the chronic administration of luzindole, cell proliferation (Ki67) significantly decreased (36%) with increasing (>100%) number of neural stem cells (NSCs; GFAP+/Sox2+) in the subgranular zone of the dentate gyrus of the hippocampus. In addition, luzindole did not affect hopelessness-like behavior in the forced swim test (FST) or changes in the novelty suppressed feeding test (NST) after 14 days of treatment either neuronal activation in the dentate gyrus after FST. These results suggest that the MMRs are involved in the effects of endogenous melatonin to mediate the transition from NSCs and proliferative cells to the following developmental stages implicated in the hippocampal neurogenic process of adult female C57BL/6 mice." @default.
• W2192337112 created "2016-06-24" @default.
• W2192337112 creator A5041881899 @default.
• W2192337112 creator A5072651746 @default.
• W2192337112 creator A5089234499 @default.
• W2192337112 date "2016-04-01" @default.
• W2192337112 modified "2023-09-30" @default.
• W2192337112 title "Chronic administration of a melatonin membrane receptor antagonist, luzindole, affects hippocampal neurogenesis without changes in hopelessness-like behavior in adult mice" @default.
• W2192337112 cites W1515231442 @default.
• W2192337112 cites W1560550807 @default.
• W2192337112 cites W1852348769 @default.
• W2192337112 cites W1958029769 @default.
• W2192337112 cites W1972928390 @default.
• W2192337112 cites W1974650724 @default.
• W2192337112 cites W1993868386 @default.
• W2192337112 cites W1998179865 @default.
• W2192337112 cites W2002112050 @default.
• W2192337112 cites W2002702165 @default.
• W2192337112 cites W2003201823 @default.
• W2192337112 cites W2003625071 @default.
• W2192337112 cites W2006231656 @default.
• W2192337112 cites W2009218904 @default.
• W2192337112 cites W2010558368 @default.
• W2192337112 cites W2012957267 @default.
• W2192337112 cites W2015324181 @default.
• W2192337112 cites W2015775161 @default.
• W2192337112 cites W2024739259 @default.
• W2192337112 cites W2036241102 @default.
• W2192337112 cites W2037701234 @default.
• W2192337112 cites W2042154782 @default.
• W2192337112 cites W2042841555 @default.
• W2192337112 cites W2045481955 @default.
• W2192337112 cites W2045640921 @default.
• W2192337112 cites W2045644996 @default.
• W2192337112 cites W2046526031 @default.
• W2192337112 cites W2050746954 @default.
• W2192337112 cites W2051276744 @default.
• W2192337112 cites W2051855123 @default.
• W2192337112 cites W2055732421 @default.
• W2192337112 cites W2057572154 @default.
• W2192337112 cites W2057608998 @default.
• W2192337112 cites W2058041634 @default.
• W2192337112 cites W2066477949 @default.
• W2192337112 cites W2067055276 @default.
• W2192337112 cites W2073490622 @default.
• W2192337112 cites W2083056265 @default.
• W2192337112 cites W2089299823 @default.
• W2192337112 cites W2103040176 @default.
• W2192337112 cites W2112977759 @default.
• W2192337112 cites W2116147604 @default.
• W2192337112 cites W2120959739 @default.
• W2192337112 cites W2122352230 @default.
• W2192337112 cites W2125867161 @default.
• W2192337112 cites W2131924401 @default.
• W2192337112 cites W2138898583 @default.
• W2192337112 cites W2141560931 @default.
• W2192337112 cites W2154757857 @default.
• W2192337112 cites W2158817614 @default.
• W2192337112 cites W2162774541 @default.
• W2192337112 cites W2402351661 @default.
• W2192337112 doi "https://doi.org/10.1016/j.neuropharm.2015.11.030" @default.
• W2192337112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26686389" @default.
• W2192337112 hasPublicationYear "2016" @default.
• W2192337112 type Work @default.
• W2192337112 sameAs 2192337112 @default.
• W2192337112 citedByCount "22" @default.
• W2192337112 countsByYear W21923371122016 @default.
• W2192337112 countsByYear W21923371122017 @default.
• W2192337112 countsByYear W21923371122018 @default.
• W2192337112 countsByYear W21923371122019 @default.
• W2192337112 countsByYear W21923371122020 @default.
• W2192337112 countsByYear W21923371122021 @default.
• W2192337112 countsByYear W21923371122022 @default.
• W2192337112 countsByYear W21923371122023 @default.
• W2192337112 crossrefType "journal-article" @default.
• W2192337112 hasAuthorship W2192337112A5041881899 @default.
• W2192337112 hasAuthorship W2192337112A5072651746 @default.
• W2192337112 hasAuthorship W2192337112A5089234499 @default.
• W2192337112 hasConcept C126322002 @default.
• W2192337112 hasConcept C134018914 @default.
• W2192337112 hasConcept C136834591 @default.
• W2192337112 hasConcept C148762608 @default.
• W2192337112 hasConcept C169760540 @default.
• W2192337112 hasConcept C2776464000 @default.
• W2192337112 hasConcept C2777542384 @default.
• W2192337112 hasConcept C2778182776 @default.
• W2192337112 hasConcept C2781161787 @default.
• W2192337112 hasConcept C2781176699 @default.
• W2192337112 hasConcept C2781269140 @default.
• W2192337112 hasConcept C2781416619 @default.
• W2192337112 hasConcept C2781461022 @default.
• W2192337112 hasConcept C28328180 @default.
• W2192337112 hasConcept C4746552 @default.
• W2192337112 hasConcept C71924100 @default.
• W2192337112 hasConcept C86803240 @default.
• W2192337112 hasConcept C95444343 @default.
• W2192337112 hasConceptScore W2192337112C126322002 @default.
• W2192337112 hasConceptScore W2192337112C134018914 @default.

• next