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• W2192384223 startingPage "4680" @default.
• W2192384223 abstract "DNA self-assembly has emerged as a new paradigm for design of biomimetic membrane channels. Several experimental groups have already demonstrated assembly and insertion of DNA channels into lipid bilayer membranes; however, the structure of the channels and their conductance mechanism have remained undetermined. Here, we report the results of molecular dynamics simulations that characterized the biophysical properties of the DNA membrane channels with atomic precision. We show that, while overall remaining stable, the local structure of the channels undergoes considerable fluctuations, departing from the idealized design. The transmembrane ionic current flows both through the central pore of the channel as well as along the DNA walls and through the gaps in the DNA structure. Surprisingly, we find that the conductance of DNA channels depend on the membrane tension, making them potentially suitable for force-sensing applications. Finally, we show that electro-osmosis governs the transport of druglike molecules through the DNA channels." @default.
• W2192384223 created "2016-06-24" @default.
• W2192384223 creator A5008976394 @default.
• W2192384223 creator A5076175038 @default.
• W2192384223 date "2015-11-12" @default.
• W2192384223 modified "2023-10-03" @default.
• W2192384223 title "Molecular Dynamics of Membrane-Spanning DNA Channels: Conductance Mechanism, Electro-Osmotic Transport, and Mechanical Gating" @default.
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• W2192384223 doi "https://doi.org/10.1021/acs.jpclett.5b01964" @default.
• W2192384223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26551518" @default.
• W2192384223 hasPublicationYear "2015" @default.
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