Matches in SemOpenAlex for { <https://semopenalex.org/work/W2192508404> ?p ?o ?g. }
- W2192508404 endingPage "361" @default.
- W2192508404 startingPage "351" @default.
- W2192508404 abstract "DNA replication stress can cause chromosomal instability and tumor progression. One key pathway that counteracts replication stress and promotes faithful DNA replication consists of the Fanconi anemia (FA) proteins. However, how these proteins limit replication stress remains largely elusive. Here we show that conflicts between replication and transcription activate the FA pathway. Inhibition of transcription or enzymatic degradation of transcription-associated R-loops (DNA:RNA hybrids) suppresses replication fork arrest and DNA damage occurring in the absence of a functional FA pathway. Furthermore, we show that simple aldehydes, known to cause leukemia in FA-deficient mice, induce DNA:RNA hybrids in FA-depleted cells. Finally, we demonstrate that the molecular mechanism by which the FA pathway limits R-loop accumulation requires FANCM translocase activity. Failure to activate a response to physiologically occurring DNA:RNA hybrids may critically contribute to the heightened cancer predisposition and bone marrow failure of individuals with mutated FA proteins." @default.
- W2192508404 created "2016-06-24" @default.
- W2192508404 creator A5007992721 @default.
- W2192508404 creator A5008992910 @default.
- W2192508404 creator A5022376007 @default.
- W2192508404 creator A5024570139 @default.
- W2192508404 creator A5032716562 @default.
- W2192508404 creator A5060337902 @default.
- W2192508404 creator A5061390507 @default.
- W2192508404 creator A5062411430 @default.
- W2192508404 creator A5079765297 @default.
- W2192508404 creator A5080896815 @default.
- W2192508404 date "2015-11-01" @default.
- W2192508404 modified "2023-10-11" @default.
- W2192508404 title "The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription" @default.
- W2192508404 cites W1496762058 @default.
- W2192508404 cites W1571913556 @default.
- W2192508404 cites W1823908009 @default.
- W2192508404 cites W1940231728 @default.
- W2192508404 cites W1968789240 @default.
- W2192508404 cites W1969127943 @default.
- W2192508404 cites W1970966311 @default.
- W2192508404 cites W1972011626 @default.
- W2192508404 cites W1973425717 @default.
- W2192508404 cites W1975993845 @default.
- W2192508404 cites W1976736675 @default.
- W2192508404 cites W1977451940 @default.
- W2192508404 cites W1979385111 @default.
- W2192508404 cites W1980052833 @default.
- W2192508404 cites W1983289953 @default.
- W2192508404 cites W1998984090 @default.
- W2192508404 cites W2004189753 @default.
- W2192508404 cites W2005115966 @default.
- W2192508404 cites W2010216792 @default.
- W2192508404 cites W2010444982 @default.
- W2192508404 cites W2015298553 @default.
- W2192508404 cites W2015805015 @default.
- W2192508404 cites W2028637581 @default.
- W2192508404 cites W2028767678 @default.
- W2192508404 cites W2034603252 @default.
- W2192508404 cites W2036176224 @default.
- W2192508404 cites W2039641528 @default.
- W2192508404 cites W2043375872 @default.
- W2192508404 cites W2043745733 @default.
- W2192508404 cites W2044292152 @default.
- W2192508404 cites W2060428945 @default.
- W2192508404 cites W2064815984 @default.
- W2192508404 cites W2065884484 @default.
- W2192508404 cites W2067466498 @default.
- W2192508404 cites W2074529613 @default.
- W2192508404 cites W2079987545 @default.
- W2192508404 cites W2084310601 @default.
- W2192508404 cites W2091477675 @default.
- W2192508404 cites W2096261947 @default.
- W2192508404 cites W2096380982 @default.
- W2192508404 cites W2101372024 @default.
- W2192508404 cites W2104301158 @default.
- W2192508404 cites W2107455041 @default.
- W2192508404 cites W2108192712 @default.
- W2192508404 cites W2109052166 @default.
- W2192508404 cites W2111786446 @default.
- W2192508404 cites W2112582433 @default.
- W2192508404 cites W2128761982 @default.
- W2192508404 cites W2129515289 @default.
- W2192508404 cites W2131229657 @default.
- W2192508404 cites W2139204366 @default.
- W2192508404 cites W2141539652 @default.
- W2192508404 cites W2142544392 @default.
- W2192508404 cites W2147822034 @default.
- W2192508404 cites W2148798204 @default.
- W2192508404 cites W2154041044 @default.
- W2192508404 cites W2154968223 @default.
- W2192508404 cites W2161887614 @default.
- W2192508404 cites W2163445749 @default.
- W2192508404 cites W2166834621 @default.
- W2192508404 cites W2166911703 @default.
- W2192508404 doi "https://doi.org/10.1016/j.molcel.2015.09.012" @default.
- W2192508404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4644232" @default.
- W2192508404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26593718" @default.
- W2192508404 hasPublicationYear "2015" @default.
- W2192508404 type Work @default.
- W2192508404 sameAs 2192508404 @default.
- W2192508404 citedByCount "271" @default.
- W2192508404 countsByYear W21925084042015 @default.
- W2192508404 countsByYear W21925084042016 @default.
- W2192508404 countsByYear W21925084042017 @default.
- W2192508404 countsByYear W21925084042018 @default.
- W2192508404 countsByYear W21925084042019 @default.
- W2192508404 countsByYear W21925084042020 @default.
- W2192508404 countsByYear W21925084042021 @default.
- W2192508404 countsByYear W21925084042022 @default.
- W2192508404 countsByYear W21925084042023 @default.
- W2192508404 crossrefType "journal-article" @default.
- W2192508404 hasAuthorship W2192508404A5007992721 @default.
- W2192508404 hasAuthorship W2192508404A5008992910 @default.
- W2192508404 hasAuthorship W2192508404A5022376007 @default.
- W2192508404 hasAuthorship W2192508404A5024570139 @default.
- W2192508404 hasAuthorship W2192508404A5032716562 @default.