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• W2192515242 abstract "Objective This study was conducted to evaluate the role of methylation of adenylate cyclase activating peptide 1 ( ADCYAP1 ), paired box gene 1 ( PAX1 ), cell adhesion molecule 1 ( CADM1 ), and T-lymphocyte maturation–associated protein ( MAL ) during carcinogenesis. Methods We evaluated the methylation of 4 genes by using the cervical carcinoma cell lines (CaSki, SiHa, HeLa, and C33A) and cervical neoplastic cells from 56 subjects with human papillomavirus 16 (HPV16)–infected low-grade squamous intraepithelial lesions (LSILs), 50 subjects with HPV16-infected high-grade squamous intraepithelial lesions (HSILs), and 24 subjects with HPV16-infected invasive cervical cancer who attended Seoul St. Mary’s Hospital. Methylation of the 4 genes was evaluated using quantitative bisulfate pyrosequencing. Results The ADCYAP1 promoter was hypermethylated in the 4 cell lines (CaSki, 97.40 ± 1.39; SiHa, 82.04 ± 17.02; HeLa, 96.14 ± 2.08; and C33A, 78 ± 10.18). PAX1 and CADM1 were hypermethylated in the HPV16/18-infected cell lines CaSki ( PAX1 , 91.18 ± 9.91; CADM1 , 93.5 ± 7.33), SiHa ( PAX1 , 96.14 ± 2.08; CADM1 , 93.15 ± 8.81), and HeLa ( PAX1 , 82.04 ± 17.02; CADM1 , 92.43 ± 9.95). MAL was hypermethylated in the CaSki cell line (96.04 ± 4.74). Among human cervical neoplastic cells, the methylation indices of ADCYAP1 were 7.8 (95% confidence interval [95% CI], 7.0–8.6) in subjects with LSILs and 39.8 (95% CI, 29.0–54.7) in those with cervical cancer ( P < 0.001); for PAX1 , 7.2 (95% CI, 6.1–8.5) and 37.8 (95% CI, 27.1–52.7), respectively; for CADM1 , 3.5 (95% CI, 3.0–4.0) and 17.7 (95% CI, 10.8–29.1), respectively; for MAL , 2.7 (95% CI, 2.5–3.0) and 13.0 (95% CI, 7.6–22.0), respectively ( P < 0.001 for each). Immunohistochemical staining results were positive in the cytoplasm of subjects with low methylation of the 4 gene promoters; however, they were negative in the cytoplasm of those with hypermethylation of the 4 gene promoters. Conclusions The results of this study suggest that the methylation of ADCYAP1 , PAX1 , CADM1 , and MAL may be highly associated with the development of cervical cancer, and that gene expression can be suppressed by gene promoter hypermethylation." @default.
• W2192515242 created "2016-06-24" @default.
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• W2192515242 date "2016-01-01" @default.
• W2192515242 modified "2023-09-24" @default.
• W2192515242 title "Methylation of Cervical Neoplastic Cells Infected With Human Papillomavirus 16" @default.
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• W2192515242 doi "https://doi.org/10.1097/igc.0000000000000582" @default.
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