Matches in SemOpenAlex for { <https://semopenalex.org/work/W2192562015> ?p ?o ?g. }
- W2192562015 abstract "In addition to its classical effects on opioid receptors, morphine can activate glia and stimulate the production of pro-inflammatory immune molecules which in turn counteract the analgesic properties of morphine. We hypothesized that decreased morphine analgesia in females may be the result of exaggerated microglial activation in brain regions critical for analgesia.Male and female rats were treated with morphine and/or minocycline and morphine analgesia was examined using the hot plate. We also examined the expression of microglial and astrocyte markers in the pain pathway.Males treated with minocycline, a microglial inhibitor, exhibited a significant increase in acute morphine analgesia as previously shown; however, morphine analgesia was not affected by minocycline pretreatment in female rats. Minocycline decreased the expression of glial activation markers in the male spinal cord and periaqueductal gray as expected; however, these same molecules were upregulated in the female.These data describe a significant difference between males and females in the behavioral effects following co-administration of morphine and minocycline." @default.
- W2192562015 created "2016-06-24" @default.
- W2192562015 creator A5011251015 @default.
- W2192562015 creator A5022580052 @default.
- W2192562015 creator A5076530091 @default.
- W2192562015 creator A5083809922 @default.
- W2192562015 date "2015-12-01" @default.
- W2192562015 modified "2023-10-17" @default.
- W2192562015 title "Examination of sex and minocycline treatment on acute morphine-induced analgesia and inflammatory gene expression along the pain pathway in Sprague–Dawley rats" @default.
- W2192562015 cites W1848247422 @default.
- W2192562015 cites W1972332198 @default.
- W2192562015 cites W1974684238 @default.
- W2192562015 cites W1975744086 @default.
- W2192562015 cites W1980674774 @default.
- W2192562015 cites W1981240408 @default.
- W2192562015 cites W1981496519 @default.
- W2192562015 cites W1986191052 @default.
- W2192562015 cites W1987692632 @default.
- W2192562015 cites W1987771359 @default.
- W2192562015 cites W1988795126 @default.
- W2192562015 cites W1993862136 @default.
- W2192562015 cites W1994787137 @default.
- W2192562015 cites W2003438800 @default.
- W2192562015 cites W2003622777 @default.
- W2192562015 cites W2008350019 @default.
- W2192562015 cites W2011398373 @default.
- W2192562015 cites W2012969740 @default.
- W2192562015 cites W2023000793 @default.
- W2192562015 cites W2024036962 @default.
- W2192562015 cites W2024424770 @default.
- W2192562015 cites W2026903066 @default.
- W2192562015 cites W2027618182 @default.
- W2192562015 cites W2030867449 @default.
- W2192562015 cites W2034279059 @default.
- W2192562015 cites W2034756951 @default.
- W2192562015 cites W2035921328 @default.
- W2192562015 cites W2042452988 @default.
- W2192562015 cites W2044862329 @default.
- W2192562015 cites W2045979065 @default.
- W2192562015 cites W2049685220 @default.
- W2192562015 cites W2052317102 @default.
- W2192562015 cites W2054461128 @default.
- W2192562015 cites W2059202382 @default.
- W2192562015 cites W2074556173 @default.
- W2192562015 cites W2081292568 @default.
- W2192562015 cites W2084737128 @default.
- W2192562015 cites W2088168096 @default.
- W2192562015 cites W2091073665 @default.
- W2192562015 cites W2095212442 @default.
- W2192562015 cites W2098139332 @default.
- W2192562015 cites W2103076324 @default.
- W2192562015 cites W2108163830 @default.
- W2192562015 cites W2109732897 @default.
- W2192562015 cites W2117622133 @default.
- W2192562015 cites W2117977770 @default.
- W2192562015 cites W2127561712 @default.
- W2192562015 cites W2128468891 @default.
- W2192562015 cites W2134858695 @default.
- W2192562015 cites W2151965291 @default.
- W2192562015 cites W2163743819 @default.
- W2192562015 cites W2164655074 @default.
- W2192562015 cites W2196308323 @default.
- W2192562015 doi "https://doi.org/10.1186/s13293-015-0049-3" @default.
- W2192562015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4676821" @default.
- W2192562015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26693004" @default.
- W2192562015 hasPublicationYear "2015" @default.
- W2192562015 type Work @default.
- W2192562015 sameAs 2192562015 @default.
- W2192562015 citedByCount "31" @default.
- W2192562015 countsByYear W21925620152016 @default.
- W2192562015 countsByYear W21925620152017 @default.
- W2192562015 countsByYear W21925620152018 @default.
- W2192562015 countsByYear W21925620152019 @default.
- W2192562015 countsByYear W21925620152020 @default.
- W2192562015 countsByYear W21925620152021 @default.
- W2192562015 countsByYear W21925620152022 @default.
- W2192562015 countsByYear W21925620152023 @default.
- W2192562015 crossrefType "journal-article" @default.
- W2192562015 hasAuthorship W2192562015A5011251015 @default.
- W2192562015 hasAuthorship W2192562015A5022580052 @default.
- W2192562015 hasAuthorship W2192562015A5076530091 @default.
- W2192562015 hasAuthorship W2192562015A5083809922 @default.
- W2192562015 hasBestOaLocation W21925620151 @default.
- W2192562015 hasConcept C126322002 @default.
- W2192562015 hasConcept C170493617 @default.
- W2192562015 hasConcept C185592680 @default.
- W2192562015 hasConcept C2776914184 @default.
- W2192562015 hasConcept C2777389121 @default.
- W2192562015 hasConcept C2777542381 @default.
- W2192562015 hasConcept C2778275353 @default.
- W2192562015 hasConcept C2779830541 @default.
- W2192562015 hasConcept C2780820201 @default.
- W2192562015 hasConcept C2781063702 @default.
- W2192562015 hasConcept C2781069035 @default.
- W2192562015 hasConcept C42219234 @default.
- W2192562015 hasConcept C501593827 @default.
- W2192562015 hasConcept C529278444 @default.
- W2192562015 hasConcept C552161191 @default.
- W2192562015 hasConcept C55493867 @default.
- W2192562015 hasConcept C71924100 @default.