FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2192637105> ?p ?o ?g. }

• W2192637105 endingPage "2910" @default.
• W2192637105 startingPage "2902" @default.
• W2192637105 abstract "5-Fluorouracil (5-FU) is one among the anti-cancer agents in FOLFORINOX treatment along with oxaliplatin and irinotecan for the treatment of colorectal cancer. Despite its potential activity on the tumor cells, it lacks site specificity partly attributed by its biodistribution to healthy cells resulting in toxic effects to healthy cells. Therefore, we have formulated 5-fluorouracil enteric-coated nanoparticles (5-FUEC) to localize the drug in the colon area that enables its prolonged presence in target area in a sustained manner. The current work emphasizes on enhanced anti-cancer activity of 5-FUEC sequencing its apoptotic activity on HCT 116 colorectal cancer cell lines in vitro. MTT assay exhibited 5.5-fold decrease in IC50 value of nanoparticles comparable to 5-FU. Nuclear fragmentation with irregular edges in nucleus of cells justified its improved activity. Furthermore, flow cytometric analysis confirms the majority of cells gated in early apoptotic (39.75%) and late apoptotic phase (36.25%). Acridine orange/ethidium bromide staining (AO/EB) exhibited cells with red fluorescence (indicating apoptosis) comparable to the control and 5-FU. γ-Scintigraphic studies determined the applicability and feasibility of the enteric coating with mean gastric emptying time, mean intestinal transit time and mean colon arrival time of 1.89 ± 0.03, 2.15 ± 0.05 and 4.03 ± 0.27 h, respectively. Moreover, nanoparticulate approach was found significant in reducing tumor size and volume in xenograft tumor models in vivo along with sustained release. These superior anti-cancer activities exhibited by 5-FUEC indicated that it could be a potential alternative to chemotherapy for colorectal cancer." @default.
• W2192637105 created "2016-06-24" @default.
• W2192637105 creator A5001159754 @default.
• W2192637105 creator A5038352499 @default.
• W2192637105 creator A5041699123 @default.
• W2192637105 creator A5075936988 @default.
• W2192637105 creator A5089237132 @default.
• W2192637105 date "2015-12-03" @default.
• W2192637105 modified "2023-09-24" @default.
• W2192637105 title "5-Fluorouracil enteric-coated nanoparticles for improved apoptotic activity and therapeutic index in treating colorectal cancer" @default.
• W2192637105 cites W1964872366 @default.
• W2192637105 cites W1984328540 @default.
• W2192637105 cites W1989439137 @default.
• W2192637105 cites W1993366459 @default.
• W2192637105 cites W2015445088 @default.
• W2192637105 cites W2016794805 @default.
• W2192637105 cites W2020885991 @default.
• W2192637105 cites W2051402860 @default.
• W2192637105 cites W2055089903 @default.
• W2192637105 cites W2088264967 @default.
• W2192637105 cites W2106292986 @default.
• W2192637105 cites W2133253864 @default.
• W2192637105 cites W2139280622 @default.
• W2192637105 cites W2149038350 @default.
• W2192637105 cites W2152276464 @default.
• W2192637105 cites W2154111801 @default.
• W2192637105 cites W2160276368 @default.
• W2192637105 cites W2170160933 @default.
• W2192637105 cites W2179681930 @default.
• W2192637105 cites W2235004388 @default.
• W2192637105 cites W2238442202 @default.
• W2192637105 cites W2917830342 @default.
• W2192637105 doi "https://doi.org/10.3109/10717544.2015.1116026" @default.
• W2192637105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26634385" @default.
• W2192637105 hasPublicationYear "2015" @default.
• W2192637105 type Work @default.
• W2192637105 sameAs 2192637105 @default.
• W2192637105 citedByCount "11" @default.
• W2192637105 countsByYear W21926371052017 @default.
• W2192637105 countsByYear W21926371052018 @default.
• W2192637105 countsByYear W21926371052019 @default.
• W2192637105 countsByYear W21926371052020 @default.
• W2192637105 countsByYear W21926371052022 @default.
• W2192637105 crossrefType "journal-article" @default.
• W2192637105 hasAuthorship W2192637105A5001159754 @default.
• W2192637105 hasAuthorship W2192637105A5038352499 @default.
• W2192637105 hasAuthorship W2192637105A5041699123 @default.
• W2192637105 hasAuthorship W2192637105A5075936988 @default.
• W2192637105 hasAuthorship W2192637105A5089237132 @default.
• W2192637105 hasBestOaLocation W21926371051 @default.
• W2192637105 hasConcept C121608353 @default.
• W2192637105 hasConcept C126322002 @default.
• W2192637105 hasConcept C150903083 @default.
• W2192637105 hasConcept C153911025 @default.
• W2192637105 hasConcept C185592680 @default.
• W2192637105 hasConcept C190283241 @default.
• W2192637105 hasConcept C207001950 @default.
• W2192637105 hasConcept C2776907736 @default.
• W2192637105 hasConcept C2779102032 @default.
• W2192637105 hasConcept C2779682216 @default.
• W2192637105 hasConcept C2780259306 @default.
• W2192637105 hasConcept C2780456651 @default.
• W2192637105 hasConcept C2780783641 @default.
• W2192637105 hasConcept C2780962732 @default.
• W2192637105 hasConcept C502942594 @default.
• W2192637105 hasConcept C526805850 @default.
• W2192637105 hasConcept C552990157 @default.
• W2192637105 hasConcept C553184892 @default.
• W2192637105 hasConcept C55493867 @default.
• W2192637105 hasConcept C71924100 @default.
• W2192637105 hasConcept C86803240 @default.
• W2192637105 hasConcept C96232424 @default.
• W2192637105 hasConcept C98274493 @default.
• W2192637105 hasConceptScore W2192637105C121608353 @default.
• W2192637105 hasConceptScore W2192637105C126322002 @default.
• W2192637105 hasConceptScore W2192637105C150903083 @default.
• W2192637105 hasConceptScore W2192637105C153911025 @default.
• W2192637105 hasConceptScore W2192637105C185592680 @default.
• W2192637105 hasConceptScore W2192637105C190283241 @default.
• W2192637105 hasConceptScore W2192637105C207001950 @default.
• W2192637105 hasConceptScore W2192637105C2776907736 @default.
• W2192637105 hasConceptScore W2192637105C2779102032 @default.
• W2192637105 hasConceptScore W2192637105C2779682216 @default.
• W2192637105 hasConceptScore W2192637105C2780259306 @default.
• W2192637105 hasConceptScore W2192637105C2780456651 @default.
• W2192637105 hasConceptScore W2192637105C2780783641 @default.
• W2192637105 hasConceptScore W2192637105C2780962732 @default.
• W2192637105 hasConceptScore W2192637105C502942594 @default.
• W2192637105 hasConceptScore W2192637105C526805850 @default.
• W2192637105 hasConceptScore W2192637105C552990157 @default.
• W2192637105 hasConceptScore W2192637105C553184892 @default.
• W2192637105 hasConceptScore W2192637105C55493867 @default.
• W2192637105 hasConceptScore W2192637105C71924100 @default.
• W2192637105 hasConceptScore W2192637105C86803240 @default.
• W2192637105 hasConceptScore W2192637105C96232424 @default.
• W2192637105 hasConceptScore W2192637105C98274493 @default.
• W2192637105 hasIssue "8" @default.
• W2192637105 hasLocation W21926371051 @default.

• next