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- W2192851234 abstract "Several light-regulated genetic circuits have been applied to spatiotemporally control transgene expression in mammalian cells. However, simultaneous regulation of multiple genes using one genetic device by light has not yet been reported. In this study, we engineered a bidirectional expression module based on LightOn system. Our data showed that both reporter genes could be regulated at defined and quantitative levels. Simultaneous regulation of four genes was further achieved in cultured cells and mice. Additionally, we successfully utilized the bidirectional expression module to monitor the expression of a suicide gene, showing potential for photodynamic gene therapy. Collectively, we provide a robust and useful tool to simultaneously control multiple genes expression by light, which will be widely used in biomedical research and biotechnology." @default.
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- W2192851234 date "2015-10-01" @default.
- W2192851234 modified "2023-10-15" @default.
- W2192851234 title "A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes" @default.
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- W2192851234 doi "https://doi.org/10.1016/j.bbrc.2015.08.085" @default.
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