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• W2192997923 abstract "The regulation of gene expression is of fundamental importance to maintain organismal function and integrity and requires a multifaceted and highly ordered sequence of events. The cyclic nature of gene expression is known as ‘transcription dynamics’. Disruption or perturbation of these dynamics can result in significant fitness costs arising from genome instability, accelerated ageing and disease. We review recent research that supports the idea that an important new role for small RNAs, particularly microRNAs (miRNAs), is in protecting the genome against short-term transcriptional fluctuations, in a process we term ‘microguarding’. An additional emerging role for miRNAs is as ‘micromessengers’—through alteration of gene expression in target cells to which they are trafficked within microvesicles. We describe the scant but emerging evidence that miRNAs can be moved between different cells, individuals and even species, to exert biologically significant responses. With these two new roles, miRNAs have the potential to protect against deleterious gene expression variation from perturbation and to themselves perturb the expression of genes in target cells. These interactions between cells will frequently be subject to conflicts of interest when they occur between unrelated cells that lack a coincidence of fitness interests. Hence, there is the potential for miRNAs to represent both a means to resolve conflicts of interest, as well as instigate them. We conclude by exploring this conflict hypothesis, by describing some of the initial evidence consistent with it and proposing new ideas for future research into this exciting topic." @default.
• W2192997923 created "2016-06-24" @default.
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• W2192997923 creator A5012338943 @default.
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• W2192997923 date "2015-09-30" @default.
• W2192997923 modified "2023-10-18" @default.
• W2192997923 title "Microguards and micromessengers of the genome" @default.
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• W2192997923 doi "https://doi.org/10.1038/hdy.2015.84" @default.
• W2192997923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4806885" @default.
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