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• W2193032951 abstract "GB-2a is a I3-naringenin-II8-eriodictyol compound isolated from Garcinia gardneriana (Planchon & Triana) Zappi, a plant used in folk medicine for the treatment of skin disorders. In the search for new depigmenting agents, this study was carried out to investigate the in vitro effects of GB-2a isolated from G. gardneriana (Planchon & Triana) Zappi in B16F10 melanoma cells. The effects of GB-2a were evaluated through determination of melanin biosynthesis in B16F10 melanoma cells in comparison with the reference drug kojic acid (500 µM). In parallel, the GB-2a effect was assessed in a cell viability assay. Mushroom tyrosinase activity assays were conducted to verify the effect of this enzyme. In order to ascertain the nature of enzyme inhibition on tyrosinase, kinetics analysis of the GB-2a was performed with l-tyrosine and l-3,4-dihydroxyphenylalanine (l-DOPA) substrates. The results showed that GB-2a biflavonoid significantly inhibited the melanin content, without reducing cell viability. GB-2a also showed a strong antityrosinase activity in the mushroom tyrosinase assay. GB-2a inhibited the tyrosinase activity, exerting a mixed inhibition. For the l-tyrosine substrate the inhibition was in non-competitive mode and for l-DOPA it was in uncompetitive mode. GB-2a biflavonoid promoted inhibition on tyrosinase activity and reduced melanin biosynthesis in B16F10 cells, which suggests great potential for medical and cosmetic uses as a depigmenting agent." @default.
• W2193032951 created "2016-06-24" @default.
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• W2193032951 date "2015-11-01" @default.
• W2193032951 modified "2023-09-25" @default.
• W2193032951 title "Inhibitory effect of GB-2a (I3-naringenin-II8-eriodictyol) on melanogenesis" @default.
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• W2193032951 doi "https://doi.org/10.1016/j.jep.2015.08.015" @default.
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