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- W2193136655 abstract "Spatial computer simulations are becoming more feasible and relevant for studies of signaling pathways due to technical advances in experimental techniques yielding better high resolution data. However, many common single particle simulation environments used in computational systems biology lack the functionality to easily implement spatially heterogeneous membrane environments.We introduce an extension to the single particle simulator Smoldyn that allows modeling of surface-dependent diffusion, without unnecessarily increasing molecular states or numbers, hence avoiding explosion of molecule and reaction definitions.We demonstrate the usefulness of this approach studying AMPA receptor diffusion at the postsynaptic density and its spatial trapping without introducing hypothetical scaffold elements or membrane barriers." @default.
- W2193136655 created "2016-06-24" @default.
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- W2193136655 date "2015-12-01" @default.
- W2193136655 modified "2023-10-06" @default.
- W2193136655 title "Enabling surface dependent diffusion in spatial simulations using Smoldyn" @default.
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- W2193136655 doi "https://doi.org/10.1186/s13104-015-1723-6" @default.
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