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• W2193203205 startingPage "249" @default.
• W2193203205 abstract "This chapter reviews the occurrence in vitro of malignant transformation, both spontaneous and induced, and associated morphological and physiological changes. Under the various culture conditions used spontaneous malignant transformation is a reproducible phenomenon occurring in cells from many tissues and species. As malignant neoplasm is usually defined as a progressively growing autonomous tumor, a malignant transformation of cells in vitro denotes a change in the cells relative to the organism from which they were derived. The best test to detect this changed relationship is to return the cells to the donor organism or to an isologous host. Because of the technical difficulties and limitations of this test, other methods of transplantation have been used. These other methods are also reviewed in the chapter. Of the numerous reports of induction by tumor viruses, only a few provide strong evidence and in these it is uncertain whether the virus accelerates the spontaneous change or induces malignant transformation by a different mechanism. Most of the changes thought to be associated with malignant transformation appear to be unrelated concomitant phenomena. None of these has been shown conclusively to be the cause or consequence of the malignant change or to be sufficiently correlated with the change to serve as a reliable indicator." @default.
• W2193203205 created "2016-06-24" @default.
• W2193203205 creator A5009818150 @default.
• W2193203205 date "1965-01-01" @default.
• W2193203205 modified "2023-09-26" @default.
• W2193203205 title "Malignant Transformation of Cells in Vitro" @default.
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