FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2193207784> ?p ?o ?g. }

• W2193207784 endingPage "3684" @default.
• W2193207784 startingPage "3673" @default.
• W2193207784 abstract "The identification of subjects at high risk for Alzheimer’s disease is important for prognosis and early intervention. We investigated the polygenic architecture of Alzheimer’s disease and the accuracy of Alzheimer’s disease prediction models, including and excluding the polygenic component in the model. This study used genotype data from the powerful dataset comprising 17 008 cases and 37 154 controls obtained from the International Genomics of Alzheimer’s Project (IGAP). Polygenic score analysis tested whether the alleles identified to associate with disease in one sample set were significantly enriched in the cases relative to the controls in an independent sample. The disease prediction accuracy was investigated in a subset of the IGAP data, a sample of 3049 cases and 1554 controls (for whom APOE genotype data were available) by means of sensitivity, specificity, area under the receiver operating characteristic curve (AUC) and positive and negative predictive values. We observed significant evidence for a polygenic component enriched in Alzheimer’s disease (P = 4.9 × 10−26). This enrichment remained significant after APOE and other genome-wide associated regions were excluded (P = 3.4 × 10−19). The best prediction accuracy AUC = 78.2% (95% confidence interval 77–80%) was achieved by a logistic regression model with APOE, the polygenic score, sex and age as predictors. In conclusion, Alzheimer’s disease has a significant polygenic component, which has predictive utility for Alzheimer’s disease risk and could be a valuable research tool complementing experimental designs, including preventative clinical trials, stem cell selection and high/low risk clinical studies. In modelling a range of sample disease prevalences, we found that polygenic scores almost doubles case prediction from chance with increased prediction at polygenic extremes." @default.
• W2193207784 created "2016-06-24" @default.
• W2193207784 creator A5001679374 @default.
• W2193207784 creator A5004893591 @default.
• W2193207784 creator A5010807658 @default.
• W2193207784 creator A5011863508 @default.
• W2193207784 creator A5011932191 @default.
• W2193207784 creator A5017009749 @default.
• W2193207784 creator A5017017613 @default.
• W2193207784 creator A5020514779 @default.
• W2193207784 creator A5027152344 @default.
• W2193207784 creator A5031173940 @default.
• W2193207784 creator A5033321689 @default.
• W2193207784 creator A5040490170 @default.
• W2193207784 creator A5040508278 @default.
• W2193207784 creator A5044019097 @default.
• W2193207784 creator A5047373823 @default.
• W2193207784 creator A5058572359 @default.
• W2193207784 creator A5061975789 @default.
• W2193207784 creator A5064532444 @default.
• W2193207784 creator A5065920088 @default.
• W2193207784 creator A5068515931 @default.
• W2193207784 creator A5071831090 @default.
• W2193207784 creator A5077506936 @default.
• W2193207784 creator A5079385332 @default.
• W2193207784 creator A5081113043 @default.
• W2193207784 creator A5085651175 @default.
• W2193207784 creator A5085975040 @default.
• W2193207784 creator A5091305213 @default.
• W2193207784 date "2015-10-21" @default.
• W2193207784 modified "2023-10-12" @default.
• W2193207784 title "Common polygenic variation enhances risk prediction for Alzheimer’s disease" @default.
• W2193207784 cites W1797408175 @default.
• W2193207784 cites W1912691389 @default.
• W2193207784 cites W1966831629 @default.
• W2193207784 cites W1992436001 @default.
• W2193207784 cites W2006736564 @default.
• W2193207784 cites W2038003677 @default.
• W2193207784 cites W2054344703 @default.
• W2193207784 cites W2059867286 @default.
• W2193207784 cites W2071068165 @default.
• W2193207784 cites W2098597355 @default.
• W2193207784 cites W2100721190 @default.
• W2193207784 cites W2102416906 @default.
• W2193207784 cites W2115779804 @default.
• W2193207784 cites W2121820194 @default.
• W2193207784 cites W2123971761 @default.
• W2193207784 cites W2132297623 @default.
• W2193207784 cites W2132947674 @default.
• W2193207784 cites W2135665336 @default.
• W2193207784 cites W2139294612 @default.
• W2193207784 cites W2142143138 @default.
• W2193207784 cites W2145210308 @default.
• W2193207784 cites W2152119060 @default.
• W2193207784 cites W2161633633 @default.
• W2193207784 cites W2166501262 @default.
• W2193207784 cites W2168317986 @default.
• W2193207784 cites W2170197613 @default.
• W2193207784 cites W3214092816 @default.
• W2193207784 doi "https://doi.org/10.1093/brain/awv268" @default.
• W2193207784 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5006219" @default.
• W2193207784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26490334" @default.
• W2193207784 hasPublicationYear "2015" @default.
• W2193207784 type Work @default.
• W2193207784 sameAs 2193207784 @default.
• W2193207784 citedByCount "325" @default.
• W2193207784 countsByYear W21932077842015 @default.
• W2193207784 countsByYear W21932077842016 @default.
• W2193207784 countsByYear W21932077842017 @default.
• W2193207784 countsByYear W21932077842018 @default.
• W2193207784 countsByYear W21932077842019 @default.
• W2193207784 countsByYear W21932077842020 @default.
• W2193207784 countsByYear W21932077842021 @default.
• W2193207784 countsByYear W21932077842022 @default.
• W2193207784 countsByYear W21932077842023 @default.
• W2193207784 crossrefType "journal-article" @default.
• W2193207784 hasAuthorship W2193207784A5001679374 @default.
• W2193207784 hasAuthorship W2193207784A5004893591 @default.
• W2193207784 hasAuthorship W2193207784A5010807658 @default.
• W2193207784 hasAuthorship W2193207784A5011863508 @default.
• W2193207784 hasAuthorship W2193207784A5011932191 @default.
• W2193207784 hasAuthorship W2193207784A5017009749 @default.
• W2193207784 hasAuthorship W2193207784A5017017613 @default.
• W2193207784 hasAuthorship W2193207784A5020514779 @default.
• W2193207784 hasAuthorship W2193207784A5027152344 @default.
• W2193207784 hasAuthorship W2193207784A5031173940 @default.
• W2193207784 hasAuthorship W2193207784A5033321689 @default.
• W2193207784 hasAuthorship W2193207784A5040490170 @default.
• W2193207784 hasAuthorship W2193207784A5040508278 @default.
• W2193207784 hasAuthorship W2193207784A5044019097 @default.
• W2193207784 hasAuthorship W2193207784A5047373823 @default.
• W2193207784 hasAuthorship W2193207784A5058572359 @default.
• W2193207784 hasAuthorship W2193207784A5061975789 @default.
• W2193207784 hasAuthorship W2193207784A5064532444 @default.
• W2193207784 hasAuthorship W2193207784A5065920088 @default.
• W2193207784 hasAuthorship W2193207784A5068515931 @default.
• W2193207784 hasAuthorship W2193207784A5071831090 @default.
• W2193207784 hasAuthorship W2193207784A5077506936 @default.

• next