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- W2193303267 abstract "SummaryD ECREASEDTOTALBLEEDINGEVENTSWITHREDUCEDDOSES OF ENOXAPARIN VERSUS UNFRACTIONATEDHEPARIN IN HIGH RISK UNSTABLE ANGINA In this prospective, randomized and controlled study,we compare complications in 2 groups of patients:group 1, enoxaparin 0.8 mg/kg, subcutaneous ev-ery 12 hours during 5 days, and group 2, intrave-nous unfractionated heparin during 5 days, by infu-sion treated to activate partial tromboplastin time 1.5-2 the upper limit of normal. Blood samples wereobtained at 4, 12, 24 hours and at day 5 of treat-ment, to measure anti-Xa levels, and also, evaluat-ed end points at 30 days, between groups. Univari-ate and multivariate logistic regression analyses wereperformed with clinical and angiographic variablesbetween groups, with p < 0.05. Results: 203 con-secutive patients, average age of 60.5 ± 11.2 years,and 80% men, were included. There were no differ-ences in clinical and angiographic characteristics.All patients with enoxaparin had therapeutic levelsof anti-Xa, of 0.5 to 0.67 U/mL. There was increas-ing risk of total bleeding in group 2 (18.7%) than ingroup 1 (5.6%), with RR = 1.72 (95% CI 1.29,2.29),p = .003. Also, there was 33.3% of MACE in group2, and only 17.8% in group 1, with RR = 1.88 (CI" @default.
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- W2193303267 date "2002-01-09" @default.
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- W2193303267 title "Disminución de hemorragias totales con dosis reducidas de enoxaparina en angina inestable de alto riesgo. Estudio ENHNFAI. (ENoxaparina vs Heparina No Fraccionada en Angina Inestable). Informe preliminar" @default.
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