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• W2193425795 abstract "A series of acetylenic derivatives of betulonic and betulinic acids has been synthesized and characterized by 1H and 13C NMR, IR and MS spectroscopy. The structure of propargyl betulonate 4 and propargyl betulinate-DMF solvate 8A was solved by X-ray diffraction. Thermal properties were examined using a DSC technique. The resulting alkynyl derivatives, as well as betulin 1 and betulinic acid 3, were evaluated in vitro for their cytotoxic activity against human T47D breast cancer, CCRF/CEM leukemia, SW707 colorectal, murine P388 leukemia and BALB3T3 normal fibroblasts cell lines. Several of the obtained compounds have a favorable cytotoxic profile than betulin 1. Propargyl betulinate 8 was the most active derivative, being up to 3-fold more potent than betulin 1 against the human leukemia (CCRF/CEM) cell line, with an IC50 value of 3.9 μg/mL." @default.
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• W2193425795 date "2016-02-01" @default.
• W2193425795 modified "2023-10-01" @default.
• W2193425795 title "Synthesis, structure and cytotoxic activity of acetylenic derivatives of betulonic and betulinic acids" @default.
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• W2193425795 doi "https://doi.org/10.1016/j.molstruc.2015.10.102" @default.
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