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- W2193446858 abstract "Abstract Pharmaceutical antagonism of the mineralocorticoid receptor ( MR ) can protect against organ damage caused by elevated aldosterone levels in patients experiencing heart failure ( HF ), chronic kidney disease ( CKD ), primary aldosteronism, and hypertension. While traditional steroid‐based MR antagonists effectively reduce mortality rates and extend patient survival, their broad application has been limited by significant side effects, most notably hyperkalaemia. Recently, finerenone ( BAY 94‐8862) has emerged as a next‐generation non‐steroidal dihydropyridine‐based MR antagonist designed to minimize off‐target effects while maintaining potent efficacy. In this review, the outcomes of finerenone therapy in several diseases associated with MR activity are explored. The (pre‐) clinical efficacy of finerenone is compared with that of traditional steroid‐based MR antagonists. Finally, recent and ongoing clinical trials using finerenone to treat chronic HF , CKD , and diabetic nephropathy are discussed. Taken together, pre‐clinical and clinical evidence suggests that finerenone may achieve equivalent organ‐protective effects with reduced levels of electrolyte disturbance compared with traditional steroid‐based MR antagonists. This supports further clinical development of finerenone for the treatment of cardiovascular and renal disease." @default.
- W2193446858 created "2016-06-24" @default.
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- W2193446858 date "2015-12-03" @default.
- W2193446858 modified "2023-10-11" @default.
- W2193446858 title "Non-steroidal mineralocorticoid receptor antagonism for the treatment of cardiovascular and renal disease" @default.
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- W2193446858 cites W1861292728 @default.
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- W2193446858 cites W1965783061 @default.
- W2193446858 cites W1968971519 @default.
- W2193446858 cites W1971136179 @default.
- W2193446858 cites W1974312109 @default.
- W2193446858 cites W1977186839 @default.
- W2193446858 cites W2000625714 @default.
- W2193446858 cites W2000719141 @default.
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- W2193446858 cites W2012631324 @default.
- W2193446858 cites W2015666762 @default.
- W2193446858 cites W2018277228 @default.
- W2193446858 cites W2019223575 @default.
- W2193446858 cites W2021232559 @default.
- W2193446858 cites W2023943834 @default.
- W2193446858 cites W2029954091 @default.
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- W2193446858 doi "https://doi.org/10.1002/ejhf.444" @default.
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