Matches in SemOpenAlex for { <https://semopenalex.org/work/W219345456> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W219345456 abstract "The mechanism of induction during pregnancy of a rabbit lung prostaglandin omega-hydroxylase cytochrome P-450 has been investigated. This activity has been demonstrated to be induced over 100-fold in 28-day pregnant rabbits, as compared to nonpregnant rabbits. The induction is reflected by an increase in the amount of P-450/sub PG-omega/ protein as measured by Western blotting. P-450/sub PG-omega/ microsomal protein increases throughout gestation concomitant with an increase in PGE1 omega-hydroxylase activity. Elucidation of the level of induction involved extraction of RNA from rabbit lungs obtained at various days of gestation followed by in vitro translation of the RNA in the presence of TVS-methionine. Immunoprecipitation of newly synthesized P-450 and analysis of the immunoisolates by SDS-PAGE, autoradiography and densitometry of the P-450/sub PG-omega/ band revealed that the P-450/sub PG-omega/ mRNA levels followed the gestational time-dependent increase observed for both PGE1 omega-hydroxylase activity and P-450/sub PG-omega/ protein, i.e., a gradual increase peaking at 28-days, dropping precipitously to near control levels following parturition. These data suggest that control of P-450/sub PG-omega expression occurs at the transcriptional level. Western blots of human lung bronchioloalveolar-carcinoma cell lines NCL-H322 and NCL-H358 utilizing a guinea pig IgG to P-450/sub PG-omega/ detect a cross-reactive species." @default.
- W219345456 created "2016-06-24" @default.
- W219345456 creator A5015709260 @default.
- W219345456 creator A5037885531 @default.
- W219345456 creator A5043776268 @default.
- W219345456 creator A5071203003 @default.
- W219345456 creator A5079142233 @default.
- W219345456 creator A5081365529 @default.
- W219345456 creator A5090868883 @default.
- W219345456 date "1987-05-01" @default.
- W219345456 modified "2023-09-29" @default.
- W219345456 title "Regulation of rabbit lung cytochrome P-450 prostaglandin omega-hydroxylase (P-450/sub PG-omega/) during pregnancy" @default.
- W219345456 hasPublicationYear "1987" @default.
- W219345456 type Work @default.
- W219345456 sameAs 219345456 @default.
- W219345456 citedByCount "0" @default.
- W219345456 crossrefType "journal-article" @default.
- W219345456 hasAuthorship W219345456A5015709260 @default.
- W219345456 hasAuthorship W219345456A5037885531 @default.
- W219345456 hasAuthorship W219345456A5043776268 @default.
- W219345456 hasAuthorship W219345456A5071203003 @default.
- W219345456 hasAuthorship W219345456A5079142233 @default.
- W219345456 hasAuthorship W219345456A5081365529 @default.
- W219345456 hasAuthorship W219345456A5090868883 @default.
- W219345456 hasConcept C104317684 @default.
- W219345456 hasConcept C105580179 @default.
- W219345456 hasConcept C121332964 @default.
- W219345456 hasConcept C126322002 @default.
- W219345456 hasConcept C134018914 @default.
- W219345456 hasConcept C153911025 @default.
- W219345456 hasConcept C185592680 @default.
- W219345456 hasConcept C2776524530 @default.
- W219345456 hasConcept C2778815084 @default.
- W219345456 hasConcept C2779234561 @default.
- W219345456 hasConcept C2779557605 @default.
- W219345456 hasConcept C2780664492 @default.
- W219345456 hasConcept C46973012 @default.
- W219345456 hasConcept C526171541 @default.
- W219345456 hasConcept C54355233 @default.
- W219345456 hasConcept C55493867 @default.
- W219345456 hasConcept C62231903 @default.
- W219345456 hasConcept C62520636 @default.
- W219345456 hasConcept C71924100 @default.
- W219345456 hasConcept C85265743 @default.
- W219345456 hasConcept C86803240 @default.
- W219345456 hasConceptScore W219345456C104317684 @default.
- W219345456 hasConceptScore W219345456C105580179 @default.
- W219345456 hasConceptScore W219345456C121332964 @default.
- W219345456 hasConceptScore W219345456C126322002 @default.
- W219345456 hasConceptScore W219345456C134018914 @default.
- W219345456 hasConceptScore W219345456C153911025 @default.
- W219345456 hasConceptScore W219345456C185592680 @default.
- W219345456 hasConceptScore W219345456C2776524530 @default.
- W219345456 hasConceptScore W219345456C2778815084 @default.
- W219345456 hasConceptScore W219345456C2779234561 @default.
- W219345456 hasConceptScore W219345456C2779557605 @default.
- W219345456 hasConceptScore W219345456C2780664492 @default.
- W219345456 hasConceptScore W219345456C46973012 @default.
- W219345456 hasConceptScore W219345456C526171541 @default.
- W219345456 hasConceptScore W219345456C54355233 @default.
- W219345456 hasConceptScore W219345456C55493867 @default.
- W219345456 hasConceptScore W219345456C62231903 @default.
- W219345456 hasConceptScore W219345456C62520636 @default.
- W219345456 hasConceptScore W219345456C71924100 @default.
- W219345456 hasConceptScore W219345456C85265743 @default.
- W219345456 hasConceptScore W219345456C86803240 @default.
- W219345456 hasLocation W2193454561 @default.
- W219345456 hasOpenAccess W219345456 @default.
- W219345456 hasPrimaryLocation W2193454561 @default.
- W219345456 hasRelatedWork W1958387391 @default.
- W219345456 hasRelatedWork W1991313937 @default.
- W219345456 hasRelatedWork W2013506443 @default.
- W219345456 hasRelatedWork W2025661700 @default.
- W219345456 hasRelatedWork W2038909577 @default.
- W219345456 hasRelatedWork W2069328421 @default.
- W219345456 hasRelatedWork W2072624827 @default.
- W219345456 hasRelatedWork W2079204754 @default.
- W219345456 hasRelatedWork W2082106776 @default.
- W219345456 hasRelatedWork W2085061374 @default.
- W219345456 hasRelatedWork W2085803837 @default.
- W219345456 hasRelatedWork W2086379640 @default.
- W219345456 hasRelatedWork W2113099642 @default.
- W219345456 hasRelatedWork W2114969594 @default.
- W219345456 hasRelatedWork W2146662045 @default.
- W219345456 hasRelatedWork W2163446175 @default.
- W219345456 hasRelatedWork W2269078022 @default.
- W219345456 hasRelatedWork W2338899477 @default.
- W219345456 hasRelatedWork W2361668203 @default.
- W219345456 hasRelatedWork W2410168794 @default.
- W219345456 isParatext "false" @default.
- W219345456 isRetracted "false" @default.
- W219345456 magId "219345456" @default.
- W219345456 workType "article" @default.