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• W2193588086 abstract "Background . Recently, several studies suggest that galectin-9 (Gal-9) might play a pivotal role in the pathogenesis of autoimmune diseases. However, the exact role of Gal-9 in atherosclerosis remains to be elucidated. Methods . Serum Gal-9, high-sensitivity C-reactive protein (hs-CRP), interferon- (IFN-) γ , interleukin- (IL-) 4, IL-17, and transforming growth factor- (TGF-) β 1 were measured. The effect of Gal-9 on peripheral blood mononuclear cells (PBMC) was investigated in patients with normal coronary artery (NCA). Results . The lowest level of Gal-9 was found in the ST-segment elevation myocardial infarction (STEMI) group, followed by the non-ST-segment elevation ACS (NSTEACS), the NCA, and the stable angina pectoris (SAP) groups, respectively. Additionally, Gal-9 was found to be independently associated with hs-CRP, lipoprotein(a), and creatinine. Notably, Gal-9 was also noted to be an independent predictor of the Gensini score. Moreover, Gal-9 suppressed T-helper 17 (Th17) and expanded regulatory T cells (Tregs), resulting in decreased IL-17 production and increased secretion of TGF- β 1. Conclusions . Serum Gal-9 is associated with not only coronary artery disease (CAD), but also the severity of coronary arteries stenosis. Gal-9 can expand Tregs and suppress Th17 development in activated PBMC, implying that Gal-9 has the potential to dampen the development of atherosclerosis and may be a new therapy for CAD." @default.
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• W2193588086 date "2015-01-01" @default.
• W2193588086 modified "2023-10-17" @default.
• W2193588086 title "Serum Galectin-9 Levels Are Associated with Coronary Artery Disease in Chinese Individuals" @default.
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• W2193588086 doi "https://doi.org/10.1155/2015/457167" @default.
• W2193588086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4667018" @default.
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