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- W2193724823 abstract "Pluripotent stem cells, defined by an unlimited self-renewal capacity and an undifferentiated state, are best typified by embryonic stem cells. These cells have a unique cell cycle compared to somatic cells as defined by a rapid progression through the cell cycle and a minimal time spent in G1. Recent reports indicate that pluripotency and cell cycle regulation are mechanistically linked. In this review, we discuss the reciprocal co-regulation of these processes, how this co-regulation may prevent differentiation, and how cellular reprogramming can re-establish the unique cell cycle regulation in induced pluripotent stem cells." @default.
- W2193724823 created "2016-06-24" @default.
- W2193724823 creator A5008093685 @default.
- W2193724823 creator A5073510275 @default.
- W2193724823 creator A5081385535 @default.
- W2193724823 date "2015-12-01" @default.
- W2193724823 modified "2023-10-13" @default.
- W2193724823 title "Crosstalk between stem cell and cell cycle machineries" @default.
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- W2193724823 doi "https://doi.org/10.1016/j.ceb.2015.10.001" @default.
- W2193724823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4852861" @default.
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