Matches in SemOpenAlex for { <https://semopenalex.org/work/W2193732010> ?p ?o ?g. }
- W2193732010 endingPage "131" @default.
- W2193732010 startingPage "111" @default.
- W2193732010 abstract "Atherosclerosis is the leading cause of morbidity and mortality in the U.S., and is a multifactorial disease that preferentially occurs in regions of the arterial tree exposed to disturbed blood flow. The detailed mechanisms by which d-flow induces atherosclerosis involve changes in the expression of genes, epigenetic patterns, and metabolites of multiple vascular cells, especially endothelial cells. This review presents an overview of endothelial mechanobiology and its relation to the pathogenesis of atherosclerosis with special reference to the anatomy of the artery and the underlying fluid mechanics, followed by a discussion of a variety of experimental models to study the role of fluid mechanics and atherosclerosis. Various in vitro and in vivo models to study the role of flow in endothelial biology and pathobiology are discussed in this review. Furthermore, strategies used for the global profiling of the genome, transcriptome, miR-nome, DNA methylome, and metabolome, as they are important to define the biological and pathophysiological mechanisms of atherosclerosis. These omics approaches, especially those which derive data based on a single animal model, provide unprecedented opportunities to not only better understand the pathophysiology of atherosclerosis development in a holistic and integrative manner, but also to identify novel molecular and diagnostic targets." @default.
- W2193732010 created "2016-06-24" @default.
- W2193732010 creator A5031475167 @default.
- W2193732010 creator A5044880204 @default.
- W2193732010 creator A5081859612 @default.
- W2193732010 date "2016-02-01" @default.
- W2193732010 modified "2023-10-15" @default.
- W2193732010 title "The role of endothelial mechanosensitive genes in atherosclerosis and omics approaches" @default.
- W2193732010 cites W144423133 @default.
- W2193732010 cites W1481638738 @default.
- W2193732010 cites W1488015910 @default.
- W2193732010 cites W1496596350 @default.
- W2193732010 cites W1558599316 @default.
- W2193732010 cites W1571635107 @default.
- W2193732010 cites W1576773659 @default.
- W2193732010 cites W1607892649 @default.
- W2193732010 cites W1643087207 @default.
- W2193732010 cites W1693796874 @default.
- W2193732010 cites W1819194332 @default.
- W2193732010 cites W1894889351 @default.
- W2193732010 cites W1895065514 @default.
- W2193732010 cites W1917797427 @default.
- W2193732010 cites W1922669110 @default.
- W2193732010 cites W1924909341 @default.
- W2193732010 cites W1950519844 @default.
- W2193732010 cites W1953330193 @default.
- W2193732010 cites W1964113087 @default.
- W2193732010 cites W1964374372 @default.
- W2193732010 cites W1964538746 @default.
- W2193732010 cites W1964720110 @default.
- W2193732010 cites W1964856023 @default.
- W2193732010 cites W1965691046 @default.
- W2193732010 cites W1966733021 @default.
- W2193732010 cites W1966833353 @default.
- W2193732010 cites W1967296654 @default.
- W2193732010 cites W1967513025 @default.
- W2193732010 cites W1967768675 @default.
- W2193732010 cites W1968020616 @default.
- W2193732010 cites W1968125429 @default.
- W2193732010 cites W1968141837 @default.
- W2193732010 cites W196835504 @default.
- W2193732010 cites W1968472971 @default.
- W2193732010 cites W1968553256 @default.
- W2193732010 cites W1968854293 @default.
- W2193732010 cites W1970081212 @default.
- W2193732010 cites W1970699542 @default.
- W2193732010 cites W1970871266 @default.
- W2193732010 cites W1970962088 @default.
- W2193732010 cites W1971675341 @default.
- W2193732010 cites W1972436525 @default.
- W2193732010 cites W1975529354 @default.
- W2193732010 cites W1976448006 @default.
- W2193732010 cites W1976500720 @default.
- W2193732010 cites W1977649824 @default.
- W2193732010 cites W1978387124 @default.
- W2193732010 cites W1978708058 @default.
- W2193732010 cites W1979383751 @default.
- W2193732010 cites W1980465014 @default.
- W2193732010 cites W1981133110 @default.
- W2193732010 cites W1981175423 @default.
- W2193732010 cites W1981386994 @default.
- W2193732010 cites W1981588278 @default.
- W2193732010 cites W1982526058 @default.
- W2193732010 cites W1982748428 @default.
- W2193732010 cites W1982789996 @default.
- W2193732010 cites W1983074420 @default.
- W2193732010 cites W1983390546 @default.
- W2193732010 cites W1983749135 @default.
- W2193732010 cites W1984683802 @default.
- W2193732010 cites W1984699863 @default.
- W2193732010 cites W1985640183 @default.
- W2193732010 cites W1985953696 @default.
- W2193732010 cites W1986429061 @default.
- W2193732010 cites W1987638499 @default.
- W2193732010 cites W1987943440 @default.
- W2193732010 cites W1988878654 @default.
- W2193732010 cites W1990306722 @default.
- W2193732010 cites W1991547229 @default.
- W2193732010 cites W1992254322 @default.
- W2193732010 cites W1992797603 @default.
- W2193732010 cites W1993754752 @default.
- W2193732010 cites W1996001348 @default.
- W2193732010 cites W1996609966 @default.
- W2193732010 cites W1996629436 @default.
- W2193732010 cites W1997327385 @default.
- W2193732010 cites W1997684038 @default.
- W2193732010 cites W1999083451 @default.
- W2193732010 cites W1999160425 @default.
- W2193732010 cites W2000680001 @default.
- W2193732010 cites W2001132215 @default.
- W2193732010 cites W2002018258 @default.
- W2193732010 cites W2002129512 @default.
- W2193732010 cites W2002555938 @default.
- W2193732010 cites W2003081532 @default.
- W2193732010 cites W2004033129 @default.
- W2193732010 cites W2004257766 @default.
- W2193732010 cites W2004336032 @default.
- W2193732010 cites W2005886834 @default.