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- W2193911587 abstract "The interleukin (IL)-6/gp130 family of cytokines including IL-6, IL-11, leukemia inhibitory factor (LIF) and oncostatin M (OSM), play important roles in the central nervous system (CNS) during neuroinflammation and neurodevelopment. However, little is known regarding the responses of the key glial cells, astrocytes and microglia to this family of cytokines. To address this issue, the expression of the gp130 cytokine receptors and subsequent signal pathway activation was examined in cultured murine astrocytes and microglia. In astrocytes, both LIFR mRNA and OSMR mRNA were abundant while low levels of IL-6R mRNA and IL-11R mRNA were also detected. In comparison, in microglia there was no detectable LIFR mRNA and OSMR mRNA, and higher levels of IL-6R mRNA and similar levels of IL-11R mRNA. Immunoblotting for the IL-6R and OSMR proteins revealed that both astrocytes and microglia produced IL-6R, however, the OSMR was abundant in astrocytes but not detectable in microglia. Furthermore, in response to OSM, astrocytes but not microglia responded with activation of STAT3 and ERK while microglia but not astrocytes responded to IL-6. However, both cell types responded strongly to hyper-IL6, with activation of STAT3 and ERK. Finally, in both microglia and astrocytes, OSM failed to activate NF κ B or induce NOS2 and nitrite production. We conclude: (1) notable differences exist in the expression of some key IL-6/gp130 family cytokine receptors in astrocytes and microglia, and (2) the findings provide a molecular basis for the differential response to OSM by astrocytes versus microglia. Funding support: NHMRC project grant APP632754." @default.
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- W2193911587 date "2013-09-01" @default.
- W2193911587 modified "2023-10-18" @default.
- W2193911587 title "121" @default.
- W2193911587 doi "https://doi.org/10.1016/j.cyto.2013.06.124" @default.
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