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- W2193975516 abstract "Abstract Mercury is a highly hazardous and widespread heavy metal and can cause many severe health problems such as kidney failure, central nervous system damage with various cognitive and motor disorders, and even death. Efficient approach for the detection of mercury ion is very significant. In this work, a colorimetric and ratiometric fluorescent probe based on 4-chloro-7-nitrobenzo-2,1,3-oxadiazole (NBD-Cl) is developed by employing a photo-induced electron transfer mechanism. Furthermore, we were fortunate enough to obtain the single crystal structures before and after binding with Hg2+, which displays that two nitrogen atoms on amino and morpholine groups participate in the coordination and form a complex with a ratio of 2:2. And this probe displays a highly selective response to mercury (II) ions in an aqueous solution and possesses a distinguished capability for lysosome-targeting detection of Hg2+ without interferences in living cells. The results suggest that Hg2+-selective probe has good water-solubility, biocompatibility and cell-penetrability and can serve as an efficient tool for probing cellular toxicological actions that are related to Hg2+." @default.
- W2193975516 created "2016-06-24" @default.
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- W2193975516 date "2016-03-01" @default.
- W2193975516 modified "2023-10-13" @default.
- W2193975516 title "A colorimetric and ratiometric fluorescent probe for mercury (II) in lysosome" @default.
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- W2193975516 doi "https://doi.org/10.1016/j.snb.2015.11.018" @default.
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