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- W2194056660 abstract "Objective: Obesity is a multifactorial disorder associated with dyslipidemia and hepatic insulin resistance as the consequence of fatty liver accumulation. In the present study, we tested the hypothesis that exercise training or caloric restriction would reduce hepatic steatosis in obese rats. In addition, we investigated whether exercise training associated with caloric restriction would cause a more intense reduction in hepatic steatose than exercise training or caloric restriction alone. Subjects : Male Wistar rats were fed with cafeteria diet with high-fat content for 25 weeks. Then, they were randomly divided into four groups: high-fat-diet (n=13), high-fat-diet submitted to running exercise training (60% peak VO 2 , n=13), caloric restriction (-20 % of Kcal/day, n=14), and caloric restriction plus training (n=14). This period lasted 10 weeks. Results: Exercise training significantly decreased adiposity index (-23%) and leptin level (-31%) and significantly increased peak oxygen uptake (23%), but caused no changes in body weight and hepatic triglycerides and cholesterol contents. Caloric restriction decreased body weight (-18%), adiposity index (-50%), hepatic triglycerides content (-53%) and leptin (-61%) levels. Exercise training associated with caloric restriction caused decrease in body weight (-22%), adiposity index (-61%), hepatic triglycerides (-54%) and leptin (-75%) levels and, in addition, hepatic cholesterol content (-26%). Exercise associated with caloric restriction caused no significant changes serum lipids, glucose and insulin levels and HOMA-IR. Conclusion: Exercise training associated with caloric restriction is an important nonpharmacological strategy to reduce adiposity index and hepatic lipids in obese rats." @default.
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- W2194056660 date "2015-11-09" @default.
- W2194056660 modified "2023-10-18" @default.
- W2194056660 title "Exercise Training and Caloric Restriction Reduce Adiposity Index and Hepatic Lipids in Obese Rats" @default.
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- W2194056660 doi "https://doi.org/10.14800/ie.1053" @default.
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