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• W2194401669 abstract "Recognition and degradation of viral RNA are essential for antiviral innate immune responses. Cytoplasmic viral RNA is recognized by retinoic acid-inducible gene I (RIG-I)-like receptors, which trigger type I interferon (IFN) production. Secreted type I IFN activates ubiquitously expressed type I IFN receptor and induces IFN-stimulated genes (ISGs). To suppress viral replication, several nucleases degrade viral RNA. RNase L is an ISG with endonuclease activity that degrades viral RNA, producing small RNA that activates RIG-I, resulting in the amplification of type I IFN production. Moreover, recent studies have elucidated novel links between viral RNA recognition and degradation. The RNA exosome is a protein complex that includes nucleases and is essential for host and viral RNA decay. Although the small RNAs produced by the RNA exosome do not activate RIG-I, several accessory factors of the RNA exosome promote RIG-I activation. Zinc-finger antiviral protein (ZAP) is an accessory factor that recognizes viral RNA and promotes viral RNA degradation via the RNA exosome. ZAPS is an alternative splicing form of ZAP and promotes RIG-I oligomerization and ATPase activity, resulting in RIG-I activation. DDX60 is another cofactor involved in the viral RNA degradation via the RNA exosome. The DDX60 protein promotes RIG-I signaling in a cell-type specific manner. These observations imply that viral RNA degradation and recognition are linked to each other. In this review, I discuss the links between recognition and degradation of viral RNA." @default.
• W2194401669 created "2016-06-24" @default.
• W2194401669 creator A5038761597 @default.
• W2194401669 creator A5043184323 @default.
• W2194401669 creator A5053550841 @default.
• W2194401669 date "2015-12-08" @default.
• W2194401669 modified "2023-10-08" @default.
• W2194401669 title "Links between recognition and degradation of cytoplasmic viral RNA in innate immune response" @default.
• W2194401669 cites W1496462301 @default.
• W2194401669 cites W1503306485 @default.
• W2194401669 cites W1503339982 @default.
• W2194401669 cites W1529133069 @default.
• W2194401669 cites W1967953614 @default.
• W2194401669 cites W1968178474 @default.
• W2194401669 cites W1968895930 @default.
• W2194401669 cites W1969078573 @default.
• W2194401669 cites W1973646620 @default.
• W2194401669 cites W1975215291 @default.
• W2194401669 cites W1978527132 @default.
• W2194401669 cites W1978856165 @default.
• W2194401669 cites W1986360322 @default.
• W2194401669 cites W1991436313 @default.
• W2194401669 cites W1992941884 @default.
• W2194401669 cites W1993832002 @default.
• W2194401669 cites W1994034344 @default.
• W2194401669 cites W1995296637 @default.
• W2194401669 cites W1999556384 @default.
• W2194401669 cites W1999894089 @default.
• W2194401669 cites W2005043758 @default.
• W2194401669 cites W2005121650 @default.
• W2194401669 cites W2005502948 @default.
• W2194401669 cites W2006600110 @default.
• W2194401669 cites W2009518589 @default.
• W2194401669 cites W2011001330 @default.
• W2194401669 cites W2013035173 @default.
• W2194401669 cites W2014536762 @default.
• W2194401669 cites W2016131266 @default.
• W2194401669 cites W2017515700 @default.
• W2194401669 cites W2018113410 @default.
• W2194401669 cites W2018828712 @default.
• W2194401669 cites W2027470840 @default.
• W2194401669 cites W2028575270 @default.
• W2194401669 cites W2028792773 @default.
• W2194401669 cites W2031420898 @default.
• W2194401669 cites W2032948492 @default.
• W2194401669 cites W2033014371 @default.
• W2194401669 cites W2035858672 @default.
• W2194401669 cites W2038698914 @default.
• W2194401669 cites W2039361749 @default.
• W2194401669 cites W2039600824 @default.
• W2194401669 cites W2041345682 @default.
• W2194401669 cites W2041820736 @default.
• W2194401669 cites W2044635447 @default.
• W2194401669 cites W2045958044 @default.
• W2194401669 cites W2046013214 @default.
• W2194401669 cites W2048651813 @default.
• W2194401669 cites W2053476949 @default.
• W2194401669 cites W2058277625 @default.
• W2194401669 cites W2060004514 @default.
• W2194401669 cites W2064526034 @default.
• W2194401669 cites W2066691052 @default.
• W2194401669 cites W2067093319 @default.
• W2194401669 cites W2067706259 @default.
• W2194401669 cites W2072118838 @default.
• W2194401669 cites W2072171296 @default.
• W2194401669 cites W2076941967 @default.
• W2194401669 cites W2076996690 @default.
• W2194401669 cites W2078646756 @default.
• W2194401669 cites W2078792507 @default.
• W2194401669 cites W2085192138 @default.
• W2194401669 cites W2085435601 @default.
• W2194401669 cites W2086138941 @default.
• W2194401669 cites W2087004183 @default.
• W2194401669 cites W2089496467 @default.
• W2194401669 cites W2089510415 @default.
• W2194401669 cites W2093579074 @default.
• W2194401669 cites W2094191346 @default.
• W2194401669 cites W2095401221 @default.
• W2194401669 cites W2097354001 @default.
• W2194401669 cites W2098854209 @default.
• W2194401669 cites W2099610218 @default.
• W2194401669 cites W2100665873 @default.
• W2194401669 cites W2101039718 @default.
• W2194401669 cites W2106351093 @default.
• W2194401669 cites W2107458751 @default.
• W2194401669 cites W2107513655 @default.
• W2194401669 cites W2108706222 @default.
• W2194401669 cites W2111969980 @default.
• W2194401669 cites W2112523914 @default.
• W2194401669 cites W2114067488 @default.
• W2194401669 cites W2120696122 @default.
• W2194401669 cites W2121260217 @default.
• W2194401669 cites W2125566625 @default.
• W2194401669 cites W2126129565 @default.
• W2194401669 cites W2130933726 @default.
• W2194401669 cites W2131617804 @default.
• W2194401669 cites W2134631240 @default.
• W2194401669 cites W2136329789 @default.

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