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- W2194461569 endingPage "313" @default.
- W2194461569 startingPage "303" @default.
- W2194461569 abstract "Notch signaling is a highly conserved signal transduction pathway that regulates stem cell maintenance and differentiation in several organ systems. Upon activation, the Notch receptor is proteolytically processed, its intracellular domain (NICD) translocates into the nucleus and activates expression of target genes. Output, strength and duration of the signal are tightly regulated by post-translational modifications. Here we review the intracellular post-translational regulation of Notch that fine-tunes the outcome of the Notch response. We also describe how crosstalk with other conserved signaling pathways like the Wnt, Hedgehog, hypoxia and TGFβ/BMP pathways can affect Notch signaling output. This regulation can happen by regulation of ligand, receptor or transcription factor expression, regulation of protein stability of intracellular key components, usage of the same cofactors or coregulation of the same key target genes. Since carcinogenesis is often dependent on at least two of these pathways, a better understanding of their molecular crosstalk is pivotal." @default.
- W2194461569 created "2016-06-24" @default.
- W2194461569 creator A5010502376 @default.
- W2194461569 creator A5029424457 @default.
- W2194461569 creator A5036409925 @default.
- W2194461569 creator A5055339113 @default.
- W2194461569 creator A5057901100 @default.
- W2194461569 creator A5061882954 @default.
- W2194461569 date "2016-02-01" @default.
- W2194461569 modified "2023-10-16" @default.
- W2194461569 title "The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways" @default.
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