Matches in SemOpenAlex for { <https://semopenalex.org/work/W2194697488> ?p ?o ?g. }
- W2194697488 abstract "Metastatic complications are responsible for more than 90% of cancer-related deaths. The progression from an isolated tumor to disseminated metastatic disease is a multistep process, with each step involving intricate cross talk between the cancer cells and their non-cellular surroundings, the extracellular matrix (ECM). Many ECM proteins are significantly deregulated during the progression of cancer, causing both biochemical and biomechanical changes that together promote the metastatic cascade. In this review, the influence of several ECM proteins on these multiple steps of cancer spread is summarized. In addition, we highlight the promising (pre-)clinical data showing benefits of targeting these ECM macromolecules to prevent cancer progression." @default.
- W2194697488 created "2016-06-24" @default.
- W2194697488 creator A5030840310 @default.
- W2194697488 creator A5039753115 @default.
- W2194697488 creator A5041559292 @default.
- W2194697488 date "2015-10-20" @default.
- W2194697488 modified "2023-10-13" @default.
- W2194697488 title "Targeting ECM Disrupts Cancer Progression" @default.
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